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Thapsia Garganica is a common Mediterranean weed, but highly toxic to sheep and cattle, thus earning the nickname “death carrot”. Thapsigargin is a natural cytotoxin derived from the plant Thapsia Graganica. Oncologists Samuel Denmeade at Johns Hopkins University, Baltimore and his team has extensively researched methods to harness thapsigargin’s toxicity, and develop, as result, a novel … Continue reading A Promising Cancer Therapy: Thapsigargin’s Anti-Cancer Roles
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Thapsigargin is a naturally occurring tumor promoter derived from the plant Thapsia garganica. This effect is a result of emptying the intracellular calcium stores, which leads to a chain of events that causes apoptosis. What is Thapsigargin? Thapsigargin is a naturally occurring sesquiterpene lactone. Abundant research and literature have proved Thapsigargin to be tumorigenic, capable of … Continue reading What is Thapsigargin: Thapsigargin FAQ
Innovative Discoveries: Science Presented at Neuroscience 2016 Neuroscience 2016 took place November 12-16 at the San Diego Convention Center. The Society for Neuroscience’s 46th annual meeting is the premier venue for neuroscientists to meet, present emerging science, learn from experts, collaborate with peers, explore new tools and technologies, and advance careers. There were more than … Continue reading Society of Neuroscience Holds Conference in San Diego
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Beta-lactam antibiotics contain a cyclic amide ring of which mimics the structure of the terminal amino acid residues comprising the peptidoglycan matrix. It is this structure that the enzyme beta lactamase acts upon as a method of antibiotic defense, hydrolyzing the ring and compromising the structure as a result. Structure and function are intrinsically related; … Continue reading Beta Lactamase Inhibitors in Research: Anti-Seizure
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Photograph: CEO Chip Lindgren and Dr. Linda M. Liau (His Neurosurgeon.) In June 2001, our CEO Chip Lindgren suddenly found out he was diagnosed with oligodendroglioma brain cancer. He was able to buy time with world leading surgeons that have over watched breakthroughs in cancer immunotherapy (immuno-oncology) and viral oncology research. Chip was one of the first … Continue reading Oncologic Neurosurgery: My Awake Brain Surgery
Beta lactamase Mechanism Beta lactam antibiotics, like cephams and penicillin derivatives, have a four-member cyclic amide ring that inhibits the peptidoglycan layer synthesis in bacteria. A woven complex of sugar and protein pieces, these first-class bacteriocidal drugs destroy the integrity of the peptidoglycan layer. This method of bacterial cellular death is especially effective to Gram-positive bacteria … Continue reading The Ultimate Guide to Beta Lactamase
2016 is a big year for cancer research! Research from across the world has been reporting a mix of good and bad, with the scariest showing a list of alcohol-related cancer diseases and the best news of all showing a trick to cheat death. Do you drink alcohol? Did you know that alcohol can cause … Continue reading Alcohol, Cancer, and Dying: Research 2016
AG Presents is an interview series of scientists in the Life Sciences industry that share insights to what research life is like as a start-up, in a university, or at an institute and how they got there. Here we would love to introduce Milos Lazic of Jecure Therapeutics in San Diego, California, USA. AG Presents: Meet Milos of Jecure … Continue reading AG Presents: Meet Milos Lazic of Jecure Therapeutics [Ep. 1]
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As a core structure in many antibiotics, beta lactam ring is a cyclic amide. Beta lactam antibiotics almost universally inhibits bacterial cell wall synthesis and thus induces the destruction of the bacteria cell. Bacteria have evolved an enzyme that combats this antibiotic and increases resistance to death induced by antibiotic means: the beta lactamase enzyme. … Continue reading Top 7 FAQs for Beta Lactamase enzyme
The table below displays the annual support level for various research, condition, and disease categories based on grants, contracts, and other funding mechanisms used across the National Institutes of Health (NIH) as well as disease burden data published by the National Center for Health Statistics (NCHS) at the Centers for Disease Control & Prevention (CDC). At the request … Continue reading Top 15 NIH Funded Research (2015-2017)