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Reagents in Protein Purification
The key to successful protein purification is choosing the correct process and the correct media and reagents. Although purification can sometimes be a simple one-step precipitation, multiple step processes are more frequently required to attain the desired purity.
The preliminary mapping of The Human Protein Atlas project’s first detailed protein expression map was unveiled this week in Stockholm. This map, for the first time, includes a detailed display of systemic proteins, meaning of specific origin throughout the human body, with millions of high-resolution photographs showing the spatial distributions of proteins and their area of operation.
The post New Tissue Atlas Shows Protein Distribution within the Human Body appeared first on AG Blog.
In recent studies, Paullones, a class of benzazepinones, have proven to be potent inhibitors of primarily, two protein kinase families: Cyclin Dependent Kinases as well as the Glycogen Synthase Kinase family. Cyclin dependent Kinase, also known as the CDK family is critical for the regulation of specific cell cycle phases as well as subcellular organelle alignment1.
Case Western Reserve researchers have uncovered a new potential cancer therapy that reveals a 2-pronged approach of worsening and then, ultimately, conquering cancer cells. Their complex formulation of genetic and bio-chemical reagents allowed this team of researchers to discover a method of boosting the existence of a tumor-suppressing protein, p53-binding protein 1 (53BP1). In effect, this would give clinicians the power to direct cancer tissues down a path leading to their destruction.
The post Gene Repair Mechanism May Hold Key to New Cancer Treatment appeared first on AG Blog.
One of our most popular antibiotics, anisomycin, is a protein and DNA synthesis inhibitor that specializes in inhibiting the 80S ribosome network (eukaryotes). Anisomycin’s properties of inhibition become activated when concentrations are enough to effect greater than 95% of the 80S ribosome protein synthesis. Additionally, Anisomycin works by activating the stress response via the MAP kinase signal transduction pathway.
The post AG Scientific is a leading provider of antibiotics appeared first on AG Blog.
L-Buthionine sulfoximine is a specific γ-glutamylcysteine synthetase inhibitor that blocks the rate-limiting step of glutathionine biosynthesis and in doing so depletes the intracellular glutathionine pool in both cultured cells and in whole animals.
Glutathionine (GSH) is a water-soluble tripeptide composed of glutamine, cysteine, and glycine.
Reduced glutathione is the most abundant intracellular small molecule thiol present in mammalian cells and it serves as a potent intracellular antioxidant protecting cells from toxins such free radicals.
Changes in glutathionine homeostasis have been implicated in the etiology and progression of a
The broadly held idea that memory formation in the brain is the cause of protein synthesis was challenged in light of data released by US researchers. By injecting a protein synthesis inhibitor, Anisomycin, into the brain, researchers then found they could boost certain levels of neurotransmitters.
Our current knowledge… The applications of protein engineering can be found everywhere in biology. This field, known as proteomics, is a reliable means of producing novel molecules and has provided scientists a basic roadmap to understanding the essential properties of proteins. Therefore to attempt a complete survey of the land is fruitless. However, it is … Continue reading Polyketide Enzymes Shuffle the Molecular Deck
A.G. Scientific, Inc. is pleased to offer Anisomycin (Product # A-1049), isolated and purified from Streptomyces griseolus. Anisomycin is a bacterial antibiotic which inhibits protein synthesis by binding to 60S ribosomal subunits and blocking peptide bond formation. This prevents protein elongation and causing polysome stabilization. This action of Anisomycin monitored the cells for chromosomal DNA degradation and apoptosis.1-5 … Continue reading Anisomycin – Protein Synthesis Inhibitor
Life originated on Earth first because of light, as we discussed last week (How Did Protein Synthesis Originate?). Life originated in the presence of Earth’s day and night cycles that most present-day organisms (from bacteria to plants to animals) come equipped with a rich internal clock system that dictates many different behaviors at different times of the day.