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Geldanamycin - 1x1 mg$55.00
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Product Description
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90).
Hsp90 is a protein chaperone that binds to signaling proteins, known as "client proteins." These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others.
17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins.
Attached is a part of published references from researchers who have used our 17-AAG product. We respectfully thank them for their trust in our product. Inquire for a full reference list.
Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation, Casey Cook, et al., Hum. Mol. Genet., Jul 2012; 21: 2936 - 2945.
CELL BIOLOGY: Regulated Binding of Importin-α to Protein Kinase C in Response to Apoptotic Signals Facilitates Nuclear Import, Tariq S. Adwan, et al., J. Biol. Chem., Oct 2011; 286: 35716 - 35724.
THERAPEUTICS, TARGETS, AND CHEMICAL BIOLOGY: The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models, Melissa J. LaBonte, et al., Cancer Res., May 2011; 71: 3635 - 3648.
Pharmacokinetic Assessment of the Uptake of 16β-18F-Fluoro-5-Dihydrotestosterone (FDHT) in Prostate Tumors as Measured by PET, Bradley J. Beattie, et al., J. Nucl. Med., Feb 2010; 51: 183 - 192.
GENE REGULATION: Hsp90 Directly Modulates the Spatial Distribution of AF9/MLLT3 and Affects Target Gene Expression Jeffrey J. Lin and Charles S. Hemenway, J. Biol. Chem., Apr 2010; 285: 11966 - 11973.
MYELOID NEOPLASIA: Bag1 directly routes immature BCR-ABL for proteasomal degradation, Fujiko Tsukahara and Yoshiro Maru, Blood, Nov 2010; 116: 3582 - 3592.
MEDICAL SCIENCES: Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization, O. Jameel Shah, et al., PNAS, Jul 2010; 107: 12634 - 12639.
MECHANISMS OF SIGNAL TRANSDUCTION: Cooperative Regulation of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by Core Components of the Molecular Chaperone Machinery, Vikram Narayan, et al. J Biol Chem. 2009 September 18; 284(38): 25889–25899.
RESEARCH ARTICLES: Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase, Jian Zuo, et al., J. Exp. Biol., Apr 2008; 211: 1102 - 1108.
Additional Information
| Product Number | A-1256 |
| CAS # | CAS [75747-14-7] |
| Chemical Name | 17-(Allylamino)-17-demethoxygeldanamycin, (17-AAG) |
| Chemical Formula | C31H43N3O8 |
| Appearance | Purple Powder |
| Melting Point | MP: 203-205°C |
| Molecular Weight | M.W. 585.7 |
| Purity | Purity: ≥98% |
| Solubility | DMSO, Methanol: Clear purple solution at 10mg/ml. |
| Storage Temp | -20°C |
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All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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