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17-AAG

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17-AAG

CAS: 75747-14-7 Formula: C31H43N3O8 MW: 585.7 Appearance: Purple Powder Purity: 98%
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PRODUCT # SIZE LIST PRICE QUANTITY BUY NOW BULK INQUIRIES
A-1256 500 ug
$39.70
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1 mg
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17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Hsp90 is a protein chaperone that binds to signaling proteins, known as client proteins. These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others.17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins.Attached here are a few published references from researchers who have used our 17-AAG product. We respectfully thank them for their trust in our product.Pharmacokinetic Assessment of the Uptake of 16-18F-Fluoro-5-Dihydrotestosterone (FDHT) in Prostate Tumors as Measured by PET.Hsp90 Directly Modulates the Spatial Distribution of AF9/MLLT3 and Affects Target Gene Expression.Cooperative Regulation of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by Core Components of the Molecular Chaperone Machinery.Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation.Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization.Bag1 directly routes immature BCR-ABL for proteasomal degradation.Regulated Binding of Importin- to Protein Kinase C in Response to Apoptotic Signals Facilitates Nuclear Import.The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models.Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase.

Additional Information

Synonyms Tanespimycin
Product # A-1256
CAS # 75747-14-7
Chemical Name 17-(Allylamino)-17-demethoxygeldanamycin
Formula C31H43N3O8
MW 585.7
Appearance Purple Powder
Purity 98%
Solubility Soluble in Water
Melting Point 203-205°C
Storage Temp -20°C
Therapeutic Area Oncological Disorders
Use A potent Hsp90 inhibitor for tumor cells

Additional Information

MDL Number MFCD04973892
ChemACX X1367336-8
InChI InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10-,20-15-/t17-,19+,24+,25+,27-,29+/m1/s1
SMILES C[C@H]1C[C@@H]([C@@H]([C@H](/C=C([C@@H]([C@H](/C=CC=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)/C)C)O)OC

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GHS Pictograms
Handling Store in tightly Sealed Vial Protect from Light

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msds 1 A-1256_A-1256,_17-AAG,_MSDS.pdf
Certificate of Analysis 1 A-1256, E1348D.pdf
Certificate of Analysis 2 A-1256 E1348A.pdf
Certificate of Analysis 3 A-1256, E1177.pdf

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17-AAG

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