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17DMAG

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17DMAG

CAS: 467214-20-6 Formula: C32H48N4O8 MW: 616.8 Appearance: Purple Powder Purity: 98% by TLC
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PRODUCT # SIZE LIST PRICE QUANTITY BUY NOW BULK INQUIRIES
A-1298 1 mg
$53.35
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5 mg
$138.72
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17-DMAG binds to Hsp90 and alters its function. A water soluble cell-permeable analog of Geldanamycin (G-1047) and 17-AAG (A-1256), 17-DMAG binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor.Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-alpha increase, and caspase-3 activation. HSP90 inhibits, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(DMAG) to increase the radiosensitivity of tumor cells in vitro. HSP90 inhibitor, 17-DMAG, enhances radiosensitivity of human cancer cells.

Additional Information

Synonyms NSC 707545
Product # A-1298
CAS # 467214-20-6
Chemical Name 17-[2- (Dimethylamino)ethyl]amino-17- desmethoxygeldanamycin
Formula C32H48N4O8
MW 616.8
Appearance Purple Powder
Purity 98% by TLC
Solubility Soluble in DMSO, Methanol, Ethanol
Boiling Point 810.5±65.0 °C at 760 mmHg
Preparation Clear purple solution at 10mg 17DMAG in 1ml of Methanol, or 25mg 17DMAG in 1ml DMSO
Storage Temp -20°C
Therapeutic Area Oncological Disorders
Use 17-DMAG is used to inhibit cancer growth and to promote apoptosis in multiple cell lines

Additional Information

MDL Number MFCD08457919
ChemACX X1578552-3
InChI InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1
SMILES C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)C)C)O)OC

Additional Information

GHS Pictograms
Handling Warning.Toxic, protect from Light

Additional Information

Certificate of Analysis 1 A-1298, F1245.pdf
Certificate of Analysis 2 A-1298_A-1298,_C1098.pdf

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17DMAG

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