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5-Aza-2'-deoxycytidine

CAS: 2353-33-5 Formula: C8H12N4O4 MW: 228.08 Appearance: White to off-white Solid Purity: 98% by HPLC
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A-2171 10 mg
$101.37
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50 mg
$378.82
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An epigenetic modifier. Decitabine is an analogue of the nucleoside 2-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. DNA hypomethylation is achieved at concentrations below those required to significantly inhibit DNA synthesis, which may promote restoration of function to genes associated with control of cellular differentiation and proliferation.

Additional Information

Synonyms Decitabine
Product # A-2171
CAS # 2353-33-5
Chemical Name 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-triazin-2(1H)-one; Decitabine
Formula C8H12N4O4
MW 228.08
Appearance White to off-white Solid
Purity 98% by HPLC
Solubility DMSO (25 mg/ml), 50% acetic acid (25 mg/ml)
Boiling Point 485.8±55.0 °C at 760 mmHg
Storage Temp -20°C
Therapeutic Area Oncological Disorders
Use It is used as anticancer agent

Additional Information

MDL Number MFCD00043011
ChemACX X1013593-6
InChI InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
SMILES c1nc(nc(=O)n1[C@H]2C[C@@H]([C@H](O2)CO)O)N

Additional Information

GHS Pictograms
RTECS XZ3012000
Handling Protect from air and moisture

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5-Aza-2'-deoxycytidine

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