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A cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase (PKG), slows or inhibits the intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine. It inhibits thrombin stimulated arachidonic acid release in human platelets.
|Chemical Name||8- Bromoguanosine- 3', 5'- cyclic monophosphate, cyclic 8- bromoguanosine- 3', 5'- monophosphate, 8- bromoguanosine- 3', 5'-monophosphate|
|Chemical Formula||C10H10BrN5O7P. Na|
|Appearance||White to off-white solid|
|Purity||≥95% by TLC|
|Solubility||H2O (~25 mg/ml) or aqueous buffers|
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