|
|
|
|
|
Alsterpaullone
[A1136]
|
Description: Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. Alsterpaullone is a potent inhibitor of CDK1/cyclin B (IC50=0.035uM). High in vitro anti-tumor potency.
Chemical Formula: C16H11N3O3
Chemical Name: : 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
Molecular Weight: M.W. 293.3
Solubility: Soluble in DMSO; Insoluble in Water.
Active Product: N
Appearance: Brown Powder
Purity: >95%
Handling: Store in Tightly Sealed Vial. Protect from Moisture.
Storage: +4°C.
Shipping: Express Courier
Literature Reference: 1. Leost, M. et al., Paullones are Potent Inhibitors of Glycogen Synthase Kinase-3beta and Cyclin-Dependent Kinase 5/p25., 2000., 267(19):, 5983-5994., 2. Sausville, E.A. et al..
Literature Reference: Inhibition of CDKs as a Therapeutic Modality, Ann. NY Acad. Sci., 2000., 910:, 207-221., 3. Schultz, C. et al..
Literature Reference: Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/cyclin B Inhibition, and In Vitro Antitumor Activity., J. Med. Chem., 1999., 42(15):, 909-919..
Bulk Quantity: Inquire
|
|
|
To ADD this item on your order fill in the fields below and select the 'Add to Order' button. Otherwise select the 'Don't Add' button.
Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
|
|
|
|
|
