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Tyrphostin AG1478
[A1296]
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PRODUCT NAME: Tyrphostin AG 1478
ALT NAME: 4-(3-Chloroanillino)-6,7-dimethoxyquinazoline
CHEMICAL FORMULA: C16H14ClN3O2
MW: 315.8
CAS 174178-82-2
PURITY: >=98%.
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO.
STORAGE: -20°C. Store tightly sealed in the dark, protect from light.
Literature References: 1) Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activated ras-stimulated intestinal epithelial cells: S. Zushi, et al.; Int. J. Cancer 73, 917 (1997). 2) Inhibition of epidermal growth factor receptor kinase induces protease- dependent apoptosis in human colon cancer cells: W.E. Karnes, et al.; Gastroenterology 114, 930 (1998). 3) Apoptosis and growth inhibition of head and neck tumor cell line induced by epidermal growth factor receptor tyrosine kinase inhibitor: R.A. Faust, et al.; Oral Oncol. 35, 290 (1999). 3)Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro: G. Partik, et al.; J. Cancer Res. Clin. Oncol. 125, 379 (1999).
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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