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Clobenpropit.Dihydrobromide, VUF 9153
[C1015]
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Description: Extremely potent and selective Histamine H3 antagonist. Effective as an anticonvulsant.
Chemical Formula: C14H17ClN4S.2HBr
Chemical Name: : N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea
Molecular Weight: M.W. 470.66
Solubility: Readily Soluble in Water, DMSO and Ethanol.
CAS Number: CAS [145231-45-4]
Boiling Point / Melting Point: BP/MP: 215-216°C
Active Product: N
Appearance: White Solid
Purity: >98%
Handling: Hygroscopic. Store in Tightly Sealed Vial. Protect from Moisture.
Storage: +4°C.
Shipping: Express Courier
Literature Reference: 1. Van der Goot, H., M.J.P. Schepers, G.J. Sterk and H. Timmerman., Isothiourea Analogues of Histamine as Potent Agonists or Antagonists of the Histamine H3 Receptor., 1992., 27:, 511., 2.Yokoyama, H., et al..
Literature Reference: Clobenpropit (VUF-9153), A New Histamine H3 Receptor Antagonist, Inhibits Electrically Induced Convulsions in Mice., European Journal of Pharmacology., 1994., 260:, 23-28., 3. Poli, E., C. Pozzoli, G. Bertaccini..
Literature Reference: Interaction between Histamine H3 Receptors and Other Prejunctional Receptor Systems in Isolated Guinea Pig Duodenum., Journal of Pharmacology and Experimental Therapeutics., 1997., 281(1):, 293-299., 4. Schlicker, E., M. Kathman, H. Bitschnau, I. Marr, S. Reidmeister, H. Starki, W. Schunack..
Literature Reference: Potencies of Antagonists Chemically Related to Iodoproxyfan at Histamine H3 Receptors in the Mouse Brain Cortex and Guinea-Pig Ileum: Evidence for H3 Receptor Heterogeneity?, Naunyn-Schmiedebergs Archives of Pharmacology., 1996., 353(5):, 482-488., 5. Mochizuki, T., F.P. Jansen, R. Leurs, A.D. Windhorst, A. Yamatodani, K. Maeyama, H. Timmerman..
Literature Reference: Brain Penetration of the Histamine H3 Receptor Antagonists Thioperamide and Clobenpropit in Rat and Mouse, determined with Ex Vivo [125I] Iodophenpropit Binding., Brain Research., 1996., 743(1-2):, 178-183., 6. Coruzzi, G., E. Gabarelli, G. Bertaccini, H. Timmerman..
Bulk Quantity: Inquire
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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