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Cyclopiazonic acid, Penicillium cyclopium [C1025]
Description: Reversible inhibitor of endoplasmic reticulum Ca2+ ATPase. Does not increase IP3 levels.
Chemical Formula: C20H20N2O3
Molecular Weight: M.W. 336.4
Solubility: Soluble in Methylene Chloride and Methanol.
CAS Number: CAS [18172-33-3]
Boiling Point / Melting Point: BP/MP: 243-245°C
Active Product: N
Appearance: Off-White Crystals
Purity: >97%
Handling: Potent Neurotoxin. Wear gloves/mask when handling this product. Avoid contact by all modes of exposure.
Storage: -20°C.
Shipping: Express Courier
Literature Reference: 1. Teshima, R., J. Onose, H. Ikebuchi, J. Sawada., Ca2+-ATPase Inhibitors and PKC Activation Synergistically Stimulate TNF-Alpha Production in RBL-2H3 Cells., 1998., 47(8):, 328-333., 2. Avellanal, M., P. Rodrieguez, S. Barrigon..
Literature Reference: Protective Effects of Cyclopiazonic Acid on Ischemia-Reperfusion Injury in Rabit Hearts., Journal of Cardiovasc. Pharmacol., 1998., 32(5):, 845-851., 3. Franck, H., M. Storr, A. Puschmann, V. Schusdziarra, H.D. Allescher..
Literature Reference: Involvement of Intracellular Ca2+ Stores in Inhibitory Effects of NO Donor SIN-1 and cGMP., Am. Journal Physiol., 1998., 275:, G159-G168..
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