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Ciglitazone
[C1201]
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(+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione; U-63287
Description: Selective PPARy agonist (EC50=3uM).
Chemical Formula: C18H23NO3S
M.W. 333.5
Solubility: Soluble in DMSO (25mg/ml) or Ethanol.
CAS [74772-77-3]
Appearance: Off-White Solid
Purity: >98%
LITERATURE REFERENCES: 1. T.M. Wilson. The structure-activity relationship between peroxisome proliferator-activated receptor g agonism and antihyperglycemic activity of thiazolidinediones Journal of Medicinal Chemistry. 1996. 39 665-668
2. B. Lohrke Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor g in lutein cells. Journal of Endocrinology. 1998. 159: 429-439.
3. X. Xin. Peroxisome proliferator-activated receptor g ligands are potent inhibitors of angiogenesis in vitro and in vivo. Journal of Biological Chemistry. 1999. 9116-9121.
4. R.B. Clark. The nuclear receptor PPAR g and immunoregulation: PPAR g mediates inhibition of helper T cell responses. Journal of Immunology. 2000. 164: 1364-1371
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