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Geldanamycin, Streptomyces hygroscopicus
[G1047]
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Description: Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. Hsp90 is a highly conserved and very abundant protein in the cytosol of both eukaryotic and prokaryotic cells. Hsp90 plays a key role in regulating the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. Geldanamycin binds with a high affinity into the ATP binding pocket in Hsp90 and induces the degradation of proteins that require this chaperone for conformational maturation
Chemical Formula: C29H40N2O9
Molecular Weight: M.W. 560.6
Solubility: Soluble in DMSO.
CAS Number: CAS [30562-34-6] RTECS LX8920000
Active Product: Yes
Appearance: Yellow Solid
Purity: >95%
Handling: Store in Tightly Sealed Vial. Protect from Light.
Storage: -20°C.
Shipping: Express Courier
Literature Reference: 1. Whitsell, L., P.D. Sutphin, A.D. Lewis, P. Workman., Geldanamycin-Induced Association of Multiple Molecular Chaperone Proteins with Mutant p53 is Altered by Geldanamycin, an hsp90-Binding Agent., 1998., 18(3):, 1517-1524., 2. Lawson, B., J.W. Brewer, L.M Hendershot..
Literature Reference: Gelanamycin, an hsp90/GRP94-Binding Drug, Induces Increased Transcription of Endoplasmic Reticulum (ER) Chaperones Via the ER Stress Pathway., Journal of Cellular Physiology., 1998., 174(2):, 170-178., 3. Joly, G.A., M. Ayres, R.G. Kilbourn..
Literature Reference: Potent Inhibition of Inducible Nitric Oxide Synthase by Geldanamycin, A Tyrosine Kinase Inhibitor, in Endothelial, Smoothe Muscle Cells, and in Rat Aorta., FEBS Letters., 1997., 403(1):, 40-44., 4. Schulte, T.W., M.V. Blagosklonny, L. Romanova, J.F. Mushinski, B.P. Monia, J.F. Johnston..
Literature Reference: Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1-MEK-Mitogen-Activated Protein Kinase Signalling Pathway., Molecular and Cellular Biology., 1996., 16(10):, 5839-5845..
Bulk Quantity: Readily Available.
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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