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Beta-Lactamase,
[L1163]
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Beta-Lactamase, E.C.3.5.2.6, penicillin amido-beta-lactam hydrolase, isolated from the organism, Bacillus cereus 569/H9
Beta-Lactamase is a bacterial enzyme that destroys beta-lactam antibiotics. Broad sprectrum of activity against both penicillins (penicillinase or Beta I activity) and cephalosporins (cephalosporinase or Beta II activity).
The Beta-Lactamase supplied by A.G. Scientific is a mixture of two enzymes which cause the breakdown of certain antibiotics. It is used to remove penicillin and cephalosporin based antibiotics from serum samples, which are to be cultured for microbial investigation. The presence of such antibiotics in serum samples, can lead to false negatives results.
Appearance: Sterile Freeze-Dried Powder containing buffer and zinc salts.
Each vial contains: >500 Beta I Units and >50 Beta II Units
(Vial contains on average 150mg material)
Units are INTERNATIONAL units. One unit of activity is defined as the amount of enzyme that will catalyze the hydrolysis of 1.0 micromole of penicillin (beta I) or cephalosporin (beta II) per minute at 25C under the assay method conditions.
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BETA-LACTAMASE will inactivate the following antibiotics:
Beta-Lactam: Benzylpenicillin, ampicillin, amoxycillin, carbenicillin, methicillin, cloxacillin, flucloxacillin.
Cephalosporins: cephaloridine, cephalothin, cephalexin, cephazolin, cephradine*,cefuroxime*, cefoxitin*, ceftizoxime*, cefpiramide* (*require longer incubations for total inactivation).
Carbapenems: Bacillus cereus Beta-Lactamse II has been reported to hydrolyse some carbapenems.
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Storage: Store with dessicant at +4 C.
Sterilty: The vialed products are bacteriologically sterile. They are sterilized by gamma irradiation. No detectable growth in Nutrient Broth at 37 °C for fourteen days.
Product is BSE Free
Reconstitute one vial in 5 ml sterile water
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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