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MnTBAP
[M1018]
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Description: Cell permeable SOD mimetic. Also a peroxynitrite scavenger but not a Nitric Oxide scavenger.
Chemical Formula: C48H30MnN408
Chemical Name: : Manganese (III) tetrakis (4-benzoic acid)porphyrin
Molecular Weight: M.W. 845.7
Solubility: Dissolve at 0.1 M in aqueous base, then buffer to pH 7.0 or as needed.
Active Product: N
Appearance: Crystalline Solid
Purity: >95%
Handling: Store in Tightly Sealed Vial. Protect from Moisture.
Storage: +4°C.
Shipping: Express Courier
General Comments: For comprehensive literature review, please call (858) 452-9925.
Literature Reference: 1. Faulkner, K.M., S.I. Liochev, I. Fridovich., Stable Mn(III) Porphyrins Mimic Superoxide Dismutase In Vitro and Substitute for it In Vivo., 1994., 269(38):, 23471-23476., 2.Zingarelli, B., B.J. Day, J.D. Crapo, A.L. Salzman, C. Szabo..
Literature Reference: The Potential Role of Peroxynitrite in the Vascular Contractile and Cellular Energetic Failure in Endotoxic Shock., British Journal of Pharmacology., 1997., 120(2):, 259-267., 3. Szabo, C., B.J. Day, A.L. Salzman..
Literature Reference: Evaluation of the Relative Contribution of Nitric Oxide and Peroxynitrite to the Suppression of Mitochondrial Respiration in Immunostimulated Macrophages using a Manganese Mesoporphyrin SuperoxideDismutase Mimetic and Peroxynitrite Scavenger, FEBS Letters., 1996., 381(1-2):, 82-86., 4. Day, B.J., S. Shawen, S.I. Liochev, J.D. Crapo..
Literature Reference: A Metalloporphyrin Superoxide Dismutase Mimetic Protects Against Paraquat-Induced Endothelial Cell Injury, In Vitro., Journal of Pharmacology and Experimental Therapeutics., 1995., 275(3):, 1227-1232., 5. Cuzzocrea, S., et al..
Literature Reference: Beneficial effect of MN (II) tetrakis(4-benzoic acid) prophyrin (MNTBAP), a superoxide dismutase., Toxicology and Applied Pharmacology., 1998., 26:, 25-33., 6. Gardner, P.R., D.D. Nguyen, C.W. White..
Literature Reference: Superoxide Scavenging by Mn (II/III) tetrakis (1-methyl-4-pyridyl) Porphyrin in Mammalian Cells., Archives of Biochemistry and Biophysics., 1996., 325(1):, 20-28..
Bulk Quantity: Inquire
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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