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ODQ
[O1022]
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Description: A potent, selective inhibitor of Nitric Oxide sensitive Guanylyl Cyclase (IC50=20 nm).
Chemical Formula: `
Chemical Name: : 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one
Molecular Weight: M.W. 187.2
Solubility: Soluble in DMSO, Chloroform, and Ethylacetate.
CAS Number: CAS [41443-28-1]
Active Product: N
Appearance: Off-White to Light Yellow Powder
Purity: >98%
Handling: Store in Tightly Sealed Vial.
Storage: +4°C.
Shipping: Express Courier
General Comments: For comprehensive literature review, please call (858) 452-9925.
Literature Reference: 1. Gartwaite, J., E. Southam, C.L. Boulton, E.B. Nielson, K. Schmidt, B. Mayer., Potent and Selective Inhibition of Nitric Oxide-Sensitive Guanylyl Cyclase by 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one., 1995., 48(2):, 184-188:, 2. Hussain, A.S., G.S. Marks, J.F. Brien, K. Natatsu..
Literature Reference: The Soluble Guanylyl Cyclase Inhibitor 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one (ODQ) Inhibits Relaxation of Rabbit Aortic Rings Induced by Carbon Monoxide, Nitric Oxide, and Glyceryl Trinitrate., Can. Journal of Physiol. Pharmacol., 1997., 75(8):, 1034-1037., 3. Abi-Gerges, N., L. Hove-Madsen, R. Fischmeister, P.F. Mery..
Literature Reference: A Comparative Study of the Effects of Three Guanylyl Cyclase Inhibitors on the L-Type Ca2+ and Muscarinic K+ Currents in Frog Cardiac Myocytes., British Journal of Pharmacology., 1997., 121(7):, 1369-1377., 4. Olgart, C., N.P. Wiklund, L.E. Gustafsson..
Literature Reference: Blockade of Nitric Oxide-Evoked Smooth Muscle Contractions by an Inhibitor of Guanylyl Cyclase. Blockade of Nitric Oxide-Evoked Smooth Muscle Contractions by an Inhibitor of Guanylyl Cyclase., Neuroreport., 1997., 8(15):, 3355-3358., 5. Olson, L.J., E.T. Knych, T.C. Herzig, J.G. Drewett..
Literature Reference: Selective Guanylyl Cyclase Inhibitor Reverses Nitric Oxide-Induced Vasorelaxation., Hypertension., 1997., 29(1 pt. 2):, 254-261., 6. Ellis, J.L...
Literature Reference: Role of Soluble Guanylyl Cyclase in the Relaxations to a Nitric Oxide Donor and to Nonadrenergic Nerve Stimulation in Guinea Pig Trachea and Human Bronchus., Journal of Pharmacology and ExperimentalTherapeutics., 1997., 280(3):, 1215-1218..
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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