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PK-11195
[P1013]
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Description: Benzodiazepine antagonist.
Chemical Formula: C21H21N2OCl
Chemical Name: : 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Molecular Weight: M.W. 352.86
Solubility: Soluble in Ethanol.
CAS Number: CAS [85532-75-8]
Active Product: N
Appearance: Light Brown Solid
Purity: >98%
Handling: Store in Tightly Sealed Vial.
Storage: Room Temperature.
Shipping: Priority Courier
Literature Reference: 1. Le Fur, G., F. Guilloux, P. Rufat, J. Benavides, A. Uzan, C. Renault, M.C. Dubroeucq, C. Gueremy., Peripheral Benzodiazepine Binding Sites: Effect of PK-11195, 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. II. In Vivo Studies., 1983., 32(16):, 1849-1856., 2.Kurumaji, A., K. Kaneko, M. Toru..
Literature Reference: Effects of Chronic Treatment with Haloperidol on [3H] PK-11195 Binding in the Rat Brain and Peripheral Tissues., Neuropharmacology., 1996., 35(8):, 1075-1079., 3. Tenn, C.C., J.M. Neu, L.P. Niles..
Literature Reference: PK-11195 Blockade of Benzodiazepine-Induced Inhibition of Forskolin-Stimulated Adenylate Cyclase Activity in the Striatum., . British Journal of Pharmacology., 1996., 119(2):, 223-228., 4. Earley, B., M. Canney, B. Clune, M. Caldwell, B.E. Leonard, J.L. Junien..
Literature Reference: The effects of MK-801, Ifenprodil, JO 1784, JO 1994, and JO 1997 on PK11195 Receptor Binding, Nitric Oxide Synthase (NO Synthase) Activity and Infarct Volume in a Mouse Model of Focal Cerebral Ischemia., Neurochem. Int., 1996., 28(5-6):, 509-521..
Bulk Quantity: Inquire
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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