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Phenamil.Methanesulfonate[25 mg]
[P1017]
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Description: A derivative of amiloride, which acts as a sodium channel blocker.
Chemical Formula: C12H12ClN7O.CH3SO3H
Chemical Name: : 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]-pyrazinecarboxamide
Molecular Weight: M.W. 401.84
Solubility: Soluble in DMSO.
CAS Number: CAS [2038-35-9]
Active Product: N
Appearance: Yellow Solid
Purity: >97%
Handling: Store in Tightly Sealed Vial.
Storage: +4 °C.
Shipping: Express Courier
General Comments: For comprehensive literature review, please call (858) 452-9925.
Literature Reference: 1. Garvin, J.L., S.A. Simon, E.J. Cragoe Jr., L.J. Mandel., Phenamil: An Irreversible Inhibitor of Sodium Channels in the Toad Urinary Bladder., 1985., 87(1):, 45-54., 2. Guia, A., N. LeBlanc, R. Bose..
Literature Reference: Effects of Phenamil on Potassium and Calcium Channels of Guinea Pig Ventricular Myocytes., Journal of Pharmacology and Experimental Therapeutics., 1995., 274(2):, 649-656., 3. Guia, A., T. Chau, D. Bose, R. Bose..
Literature Reference: Mechanism of Cardiac Inotrophy by Phenamil, an Epithelial Sodium Channel Blocker., Journal of Pharmacology and Experimental Therapeutics., 1996., 277:, 163-173., 4. Blank, U., C. Rückes, W. Clauss, T. Hofmann, H. Lindemann, G. Münker, W.M. Weber..
Literature Reference: Cystic Fibrosis and Non-Cystic-Fibrosis Human Nasal Epithelium Show Analogous Na+ Absorption and Reversible Block by Phenamil., Pflügers Archives- European Journal of Physiology., 1997., 434:, 19-24., 5. Muramoto, K., Y. Magariyama, M. Homma, I. Kawagishi, S. Sugiyama, Y. Imae, S.Kudo..
Literature Reference: Rotational Fluctuation of the Sodium-driven Flagellar Motor of Vibrio alginolyticus Induced by Binding of Inhibitors., Journal of Molecular Biology., 1996., 259:, 687-695., 6. Kojima, S., T. Atsumi, K. Muramoto, S. Kudo, I. Kawagishi, M. Homma. Vibrio alginolyticus.
Literature Reference: Mutants Resistant to Phenamil, a Specific Inhibitor of the Sodium-driven, Flagellar Motor., Journal of Molecular Biology., 1997., 265:, 310-318..
Bulk Quantity: Inquire
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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