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PD-98059
[P1019]
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Description: Cell-permeable, potent and specific inhibitor of MAP Kinase (MEK or MAPK/ERK). By selectively blocking the activity of MEK, it also inhibits the phosphorylation and activation of MAP kinase.
Chemical Formula: C16H13NO3
Chemical Name: : 2'-Amino-3'methoxyflavone
Molecular Weight: M.W. 267.3
Solubility: Soluble in DMSO.
CAS Number: CAS [167869-21-8]
Active Product: Y
Appearance: Yellow Solid
Purity: >95%
Handling: Solutions may be stored at -20°C for up to 3 months. Store in Tightly Sealed Vial. Protect from Light.
Storage: -20°C.
Shipping: Express Courier
Literature Reference: 1. Alessi, D.R., A. Cuenda, P. Cohen, D.T. Dudley, A.R. Saltiel., PD 098059 is a Specific Inhibitor of the Activiation of Mitogen-Activated Protein Kinase Kinase In Vitro and In Vivo., 1995., 270(46):, 27489-27494., 2. Reiners, J.J., J.Y. Lee, R.E. Clift, D.T. Dudley, S.P. Myrand..
Literature Reference: PD98059 is an Equipotent Antagonist of the Aryl Hydrocarbon Receptor and Inhibitor of Mitogen-Activated Protein Kinase Kinase., Molecular Pharmacology., 1998., 53(3):, 438-445., 3. Cross, D.A., C. Smythe..
Literature Reference: PD 98059 Prevents Establishment of the Spindle Assembly Checkpoint and Inhibits the G2-M Transition in Meiotic but not Mitotic Cell Cycles in Xenopus., Experimental Cell Research., 1998., 241(1):, 12-22., 4. Oldham, S.M., A.D. Cox, E.R. Reynolds, N.S. Sizemore, R.J. Coffey, Jr, C.J. Der..
Literature Reference: Ras, but not Src, Transformation of Rie-1 Epithelial Cells is dependent on Activation of the Mitogen-Activated Protein Kinase Cascade., Oncogene., 1998., 16(20):, 2565-2573., 5. Veeranna Amin, N.D., N.G. Ahn, H. Jaffe, C.A. Winters, P. Grant, H.C. Pant..
Literature Reference: Mitogen-Activated Protein Kinases (Erkl, 2) Phophorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M., Journal of Neuroscience., 1998., 18(11):, 4008-4021..
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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