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Echinomycin, Quinomycin A
[Q-1112]
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Description: Echinomycin, also called Quinomycin A, is an anti-tumor antibiotic. It demonstrates broad activity against bacteria, fungi, viruses; however, echinomycin's ability to be a potent inhibitor of Hypoxia-inducible factor-1 (HIF-1) has sparked significant research interest. The HIF-1 transcription factor plays an essential role in tumor progression and metastasis.
Synonyms: Quinomycin A, NSC-13502, Actinoleukin, Antibiotic 1491
Chemical Formula: C51H64N12O12S2
Molecular Weight: M.W. 1101.3
Solubility: Soluble in 100% ethanol or DMSO
Appearance: White to Off-White Powder
Purity: >99%
Handling: Store in Tightly Sealed Vial. Hygroscopic. Toxic. Handled only by professional scientists.
Storage: -20°C.
Shipping: Express Courier
CAS Number: CAS [512-64-1].
Bulk Quantity Available for scientific applications only. Please inquire.
References:
1.) Echinomycin, a Small-Molecule Inhibitor of Hypoxia-Inducible Factor-1 DNA-Binding Activity. Dehe Kong, Eun Jung Park, Andrew G. Stephen, Maura Calvani, John H. Cardellina, Anne Monks, Robert J. Fisher, Robert H. Shoemaker and Giovanni Melillo, Cancer Research 65, 9047-9055, October 1, 2005.
2.) Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy: R.A. Cairns, et al.; PNAS 104, 9445 (2007).
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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