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Rolipram
[R1012]
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Description: (R,S)-Rolipram is a selective inhibitor of cAMP-specific phophodiesterase, PDE IV. Inquire for lead & pricing of R-(-)-Rolipram or S-(+)-Rolipram enantiomer.
Chemical Formula: C16H21N03
Chemical Name: : (R,S)-4-[3-(Cyclopentyloxy)-4-methoxy-phenyl]-2-pyrrolidinone, ZK-62711
Molecular Weight: M.W. 275.4
Solubility: Rolipram is soluble in DMSO (to 100mM), and Ethanol.
CAS Number: CAS [61413-54-5]
Boiling Point / Melting Point: BP/MP: 132°C
Active Product: Yes
Appearance: White Solid
Purity: >98%
Handling: Store in Tightly Sealed Vial.
Storage: +4°C.
Shipping: Express Courier
Literature Reference: 1. Merck Index., 1996., 12:, 8410., 2. Liang, L., E. Beshay, G.J. Prud'homme..
Literature Reference: The Phosphodiesterase Inhibitors Pentoxifylline and Rolipram Prevent Diabetes in NOD Mice., Diabetes., 1998., 47(4):, 570-575., 3. Gonocalves de Moraes, V.L., M. Singer, B.B. Vargaftig, M. Chignard..
Literature Reference: Effects of Rolipram on Cyclic AMP Levels in Alveolar Macrophages and Lipopolysaccharide-Induced Inflammation in Mouse Lung., British Journal of Pharmacology., 1998., 123(4):, 631-636., 4. Block, F., A. Tondar, W.Schmidt, M. Schwarz..
Literature Reference: Delayed Treatment with Rolipram Protects Against Neuronal Damage Following Global Ischemia in Rats., Neuroreport., 1997., 8(17):, 3829-3832., 5. Yamashita, N., M. Miyashiro, J. Baba, A. Sawa..
Literature Reference: Rolipram, A Selective Inhibitor of Phosphodiesterase Type 4, Pronouncedly Enhanced the Forskolin-Induced Promotion of Dopamine Biosynthesis in Primary Cultured Rat Mesencephalic Neurons., Japanese Journal of Pharmacology., 1997., 75(1):, 91-95., 6. Michie, A.M., M. Lobban, T. Muller, M.M. Harnett, M.D. Houslay..
Literature Reference: Rapid Regulation of PDE-2 and PDE-4 Cyclic AMP Phosphodiesterase Activity Following Ligation of the T Cell Antigen Receptor on Thymocytes: Analysis Using the Selective Inhibitors Erythro-9-(2-hydroxy-3-nonyl)-Adenine (EHNA) and Rolipram., Cellular Signalling, 1996., 8(2):, 97-110..
Bulk Quantity: Readily Available, Please Inquire
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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