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Rapamycin, Sirolimus, RAPA, Rapamune
[R1018]
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Alternative Product ID: RAPA, Rapamune, Sirolimus, AY-22989, NSC-226080, Rapamycin, Streptomyces hygroscopicus
Description: Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway. Rapamycin’s name is derived from the native word for Easter Island, Rapi Nui.
Chemical Formula: C51H79NO13
Molecular Weight: M.W. 914.2
Solubility: Rapamycin is soluble in DMSO and Methanol.
CAS Number: CAS [53123-88-9]
Boiling Point / Melting Point: BP/MP: 183-185°C
Active Product: Y
Appearance: Yellow Solid
Purity: >98%
Handling: Hygroscopic. Protect from Light and Moisture.
Storage: -20°C.
Shipping: Express Courier
Literature Reference: 1. Merck Index., 1996., 12:, 8288., 2. Vezina, C., et al..
Literature Reference: Purification and Characterization., J. Antibiot., 1975., 28:, 721., 3. Attur, M.G., R. Patel.,.
Literature Reference: Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production., Inflamm Res., 2000., 49(1):, 20-26..
Bulk Quantity: Readily Available. Inquire for pricing.
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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