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SPERMINE NONOate, SPER/NO
[S1010]
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Description: A Nitric Oxide Donor, useful for reliable generation of Nitric Oxide (NO) in vitro or in vivo. Half Life (t1/2) for NO release at 37°C is 39 minutes1.
Half Life (t1/2) for NO release at 22°-25°C is 230 minutes1.
Chemical Formula: C10H26N602
Chemical Name: : (Z)-1-[N-(3-Ammoniopropyl)-N-[4-(3-aminopropylammonio) butyl]-amino]diazen-1-ium-1,2-diolate
Molecular Weight: M.W. 262.4
Solubility: Readily Soluble in Water.
CAS Number: CAS [136587-13-8]
Active Product: N
Appearance: White Crystalline Solid
Purity: >98%
Handling: Store in Tightly Sealed Vial. Protect from Moisture.
Storage: -20°C.
Shipping: Express Courier
Literature Reference: 1. Keefer, L.K., R.W. Nims, K.M. Davies, and D.A. Wink., NONOates (1-Substitutes Diazen-1-ium-1,2-diolates) as Nitric Oxide Donors: Convenient Nitric Oxide Dosage Forms., 1996., 268:, 281-293., 2. Smith, D.J., D. Chakravarthy, S. Pulfer, M.L. Simmons, J.A. Hrabie, M.L. Citro, et al..
Literature Reference: Nitric Oxide-Releasing Polymers Containing the [N(O)NO]- Group, Journal of Medicinal Chemistry., 1996., 39:, 1148-1156., 3. Mooradian, D.l., T.C. Hutsell, L.K. Keefer..
Literature Reference: Nitric Oxide (NO) Donor Molecules: Effects of NO Release Rate on Vascular Smooth Muscle Cell Proliferation In Vitro., Journal of Cardiovascular Pharmacology., 1995., 25(4):, 674-678., 4. Gross, S.P., N. Hogg, B. Kalyanaraman..
Literature Reference: The Antioxidant effect of Spermine NONOate in Human Low-Density Lipoprotein., Chemical Research in Toxicology., 1995., 8(5):, 800-806., 5. Keefer, L.K., D. Christodoulou, T.M. Dunams, J.A. Hrabie, C.M. Maragos, J.E. Saavedra, et al..
Literature Reference: . In Nitrosamines and Related N-Nitroso Compounds: Chemistry and Biochemistry", American Chemical Society (ACS Symposium Series 553), Washington, D.C., 1994, 136., 6. Maragos, C.M., J.M. Wang, J.A. Hrabie, J.J. Oppenheim, L.K. Keefer..
Literature Reference: Nitric Oxide / Nucleophile Complexes inhibit the In Vitro Proliferation of A375 Melanoma Cells via Nitric Oxide Release., Cancer Research., 1993., 53(3):, 564-568..
Bulk Quantity: Inquire
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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