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Suramin. Hexasodium Salt
[S1012]
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Description: Suramin is a P2x and P2y Purinergic receptor antagonist. Suramin has also been shown to be an anti-parasitic and anti-tumor agent. Inhibits angiogenesis.
Chemical Formula: C51H34N6O23S6Na6
Chemical Name: : 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid.hexasodium.
Molecular Weight: M.W. 1429.2
Solubility: Soluble in Water.
CAS Number: CAS [129-46-4]
Active Product: Yes
Appearance: White Solid
Purity: >97%
Handling: Store in Tightly Sealed Vial. Protect from Moisture.
Storage: +4 °C.
Shipping: Express Courier
Literature Reference: 1. Merck Index, 1996., 12:, 9181., 2. Zhang, Y.L., T.F. Keng, Y. Zhao, L. Wu, Z.Y. Zhang..
Literature Reference: Suramin is an Active Site-Directed, Reversible, and Tight-Binding Inhibitor of Protein-Tyrosine Phosphatases., Journal of Biological Chemistry., 1998., 270(3):, 12281-12287., `.
Literature Reference: Apoptosis and Clonogenic Cell Death in PC3 Human Prostrate Cancer Cells after Treatment with Gamma Radiation and Suramin., Radiation Research., 1997., 148(2):, 105-114., 4. Cadene, M., J. Duranton, A. North, M. Si-Tahar, M. Chignard, J.G. Bieth..
Literature Reference: Inhibtion of Neutrophil Serine Proteinases by Suramin., Journal of Biological Chemistry., 1997., 272(15):, 9950-9955., 5. Waldhoer, M., E. Bofill-Cardona, G. Mulligan, M. Freissmuth, C. Nanoff..
Literature Reference: Differential Uncoupling of A1 Adenosine and D2 Dopamine Receptors by Suramin and Didemethylated Suramin (NF037)., Molecular Pharmacology., 1998., 53(5):, 808-818., 6. Gschwendt, M., W. Kittstein, F.J. Johannes..
Literature Reference: Differential Effects of Suramin on Protein Kinase C Isoenzymes. A Novel Tool for Discriminating Protein Kinase C Activities., FEBS Letters., 1998., 421(2):, 165-168..
Bulk Quantity: Available, Please Inquire
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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