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SB-203580
[S1014]
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Description: A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP Kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.
Chemical Formula: C21H16N3FOS
Chemical Name: : 4-(4-Fluorophenyl)-2-(4-methylsulfinyl phenyl)-5-(4-pyridyl) 1H-imidazole
Molecular Weight: M.W. 377.4
Solubility: Soluble in DMSO.
Active Product: Y
Appearance: White to Off-White Solid
Purity: >98%
Handling: Warning! Toxic. May be Carcinogenic. Wear gloves and mask when handling product. Avoid contact by all modes of exposure. Protect from Light. Store in Tightly Sealed Vial.
Storage: -20°C.
Shipping: Express Courier
5mg size now offered at 10% off $250.00 list price.
Literature Reference: 1. Ward, S.G., R.V. Parry, J. Mattews, L. O'Neill., A p38 MAP Kinase Inhibitor, SB203580, inhibits CD28-Dependent T Cell Proliferation and IL-2 Production., 1997., 25(2):, 304S., 2. Schultz, H., T. Rogalla, K. Engel, J.C. Lee, M. Gaestel..
Literature Reference: The Protein Kinase Inhibitor SB203580 uncouples PMA-Induced Differentiation of HL-60 Cells from Phosphorylation of Hsp27., Cell Stress Chaperones., 1997., 2(1):, 41-49., 3. Kawasaki, H., T. Morooka, S. Shimohama, J. Kimura, T. Hirano, Y. Gotoh, E. Nishida..
Literature Reference: Activation and Involvement of p38 Mitogen-Activated Protein Kinase in Glutamate-Induced Apoptosis in Rat Cerebellar Granule Cells., Journal of Biological Chemistry., 1997., 272(30):, 18518-18521., 4. Clerk, A., P.H. Sugden..
Literature Reference: The p38-MAPK Inhibitor, SB203580, Inhibits Cardiac Stress-Activated Protein Kinase/c-Jun N-terminal Kinases (SAPKs/JNKs)., FEBS Letters., 1998., 426(1):, 93-96., 5. Ward, S.G., R.V. Parry, J. Matthews, L. O'neill..
Literature Reference: A p38 MAP Kinase Inhibitor SB203580 Inhibits CD28-Dependent T Cell Proliferation and IL-2 Production., Biochemcial Society Transactions., 1997., 245(2):, 304S., 6. Simon, C; Goepfert, H; Boyd, D..
Literature Reference: Inhibition of the p38 Mitogen-Activated Protein Kinase SB 203580 Blocks PMA-Induced Mr 92,000 type IV Collagenase Secretion and In Vitro Invasions., Cancer Research., 1998., 58(6):, 1135-1139..
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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