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Subunit A of Protein Phosphatase 2A, a.k.a.
PR65 Subunit of PP2A
[S1134]
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Subunit A of PP2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit, generating functionally diverse heterotrimers of the phosphatase.
The A subunit also serves to regulate the polycation response of the phosphatase. Mutations of the A subunit are associated with lung and colon tumors. Preparations of the A subunit are useful for further studies on its function.
Source recombinant human protein. Purity > 90% by SDS-PAGE. Apparent Mr ~ 65-kDa.
Supplied 50 ml in 50 mM Tis-HCl, pH 7.0 buffer containing 0.1 mM phenylmethanesulfonyl fluoride, 14 mM b-mercaptoethanol, 1 mM EDTA and 50% glycerol.
Maintain in aliquots at -70°C. Avoid repeated thawing.
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