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TDZD-8, Inhibitor of GSK-3b
[T1132]
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Description: Highly selective, non-ATP competitive inhibitor of GSK-3b (IC50=2µM). Binds to the active site of GSK3b. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50>100µM).
Chemical Formula: C10H10N2SO2
Chemical Name: : 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Molecular Weight: M.W. 222.3
Solubility: Soluble in DMSO.
CAS Number: N/A
Active Product: Y
Appearance: Off-White Solid
Purity: >95%
Handling: Store in Tightly Sealed Vial. Protect from Light. Packaged under Inert Gas.
Storage: +4°C.
Shipping: Priority Courier
Literature Reference: 1 First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease: A. Martinez, et al.; J. Med. Chem. 45, 1292 (2002).
Bulk Quantity: Inquire
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$120.75
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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