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U0126
[U1026]
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Description: Potent and specific inhibitor of MEK1 and MEK2. Blocks the production of inflammatory cytokines and matrix metalloproteinases. Does not inhibit PKA, PKC or CaM KII.
Chemical Formula: C18H16N6S2
Chemical Name: : 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophynyltio)butadiene
Molecular Weight: M.W. 380.5
Solubility: Soluble in DMSO.
Active Product: N
Appearance: White Solid
Purity: >98%
Handling: Store in Tightly Sealed Vial. Hygroscopic. Protect from Light.
Storage: -20°C.
Shipping: Express Courier
Literature Reference: 1. Favata, M.F., et al., Identification of a Novel Inhibitor of Mitogen-Activated Protein Kinase Kinase., 1998., 273(29):, 18623-18632., 2. Fukazawa, H., Y. Uehara..
Literature Reference: U0126 reverses Ki-ras-mediated Transformation by Blocking both Mitogen-Activated Protein Kinase and p70 S6 Kinase Pathways., Cancer Res., 2000., 60(8):, 2104-2107..
Bulk Quantity: Inquire
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Note: All products sold by A.G. Scientific are for Laboratory or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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