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a23187-free acid, WWOX, WW domain domain-containing oxidoreductase

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A23187, Free Acid

CAS: 52665-69-7 Formula: C29H37N3O6 MW: 523.6 Appearance: White Solid Purity: 98%
Hazardous

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A23187 is a carboxylic acid antibiotic derived from cultures of Streptomyces chartreusensis that transports divalent cations across cell membranes, which are usually impermeable to them. This mobile Ion - carrier  forms stable complexes with divalent cations (ions with a charge of +2). The ionophore is used in laboratories to increase intracellular Ca2+ levels in intact cells. A23187 has antibiotic properties against gram-positive Bacteria and fungi.  A23187 also induces apoptosis in some cells (e.g. mouse lymphoma cell line, or S49, and Jurkat cells). Recent clinical studies indicate that treatment of oocytes lacking a 2ndPb with A23187 at 4.5–5.0 h after ICSI (Intracytoplasmic sperm injection) is expected to be effective at preventing fertilization failure.

Additional Information

Synonyms Calcium Ionophore A23187, Calcimycin, Antibiotic A23187, Calcium Ionophore
Product # A-1020
CAS # 52665-69-7
Chemical Name 5-(METHYLAMINO)-2-[(2R,3R,6S,8S,9R,11R)-3,9,11-TRIMETHYL-8-[(1S)-1-METHYL-2-OXO-2-(1H-PYRROL-2-YL)-ETHYL]-1,7-[DIOXASPIRO[5.5]UNDEC-2-YL]METHYL]-4-BENZOXAZOLECARBOXYLIC ACID
Formula C29H37N3O6
MW 523.6
Appearance White Solid
Purity 98%
Solubility Soluble in Methanol and Acetic Acid
Melting Point 189-190°C
Boiling Point 710.3±55.0 °C at 760 mmHg
Storage Temp +4°C
Therapeutic Area Infectious Diseases
Use A23187 has antibiotic properties against gram positive bacteria and fungi

Additional Information

MDL Number MFCD00151202
ChemACX X1001942-8
InChI InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
SMILES C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)c3ccc[nH]3)C)C)O[C@H]1Cc4nc5c(o4)ccc(c5C(=O)O)NC

Additional Information

GHS Pictograms
RTECS DM4676000
Handling Warning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light Protect from Moisture.

Additional Information

msds 1 A-1020, SDS.pdf
Certificate of Analysis 1 A-1020, G1328.pdf
Certificate of Analysis 2 A-1020, G1239.pdf
Certificate of Analysis 3 A-1020, A9629A.pdf

Additional Information

A23187, Free Acid

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