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a23187-free acid, WWOX, WW domain domain-containing oxidoreductase

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A23187, Free Acid

CAS: 52665-69-7 Formula: C29H37N3O6 MW: 523.6 Appearance: White Solid Purity: 98%
Hazardous

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A-1020 5 mg
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A23187 is a mobile Ion - carrier that forms stable complexes with divalent cations (ions with a charge of +2). It also acts as a divalent cation ionophore, allowing these ions to cross cell membranes, which are usually impermeable to them. The ionophore is used in laboratories to increase intracellular Ca2+ levels in intact cellsA23187 has antibiotic properties against gram-positive Bacteria and fungi. A23187 also induces apoptosis in some cells (e.g. mouse lymphoma cell line, or S49, and Jurkat cells). 

Additional Information

Synonyms Calcium Ionophore A23187, Calcimycin, Antibiotic A23187, Calcium Ionophore
Product # A-1020
CAS # 52665-69-7
Chemical Name 5-(METHYLAMINO)-2-[(2R,3R,6S,8S,9R,11R)-3,9,11-TRIMETHYL-8-[(1S)-1-METHYL-2-OXO-2-(1H-PYRROL-2-YL)-ETHYL]-1,7-[DIOXASPIRO[5.5]UNDEC-2-YL]METHYL]-4-BENZOXAZOLECARBOXYLIC ACID
Formula C29H37N3O6
MW 523.6
Appearance White Solid
Purity 98%
Solubility Soluble in Methanol and Acetic Acid
Melting Point 189-190°C
Boiling Point 710.3±55.0 °C at 760 mmHg
Storage Temp +4°C
Therapeutic Area Infectious Diseases
Use A23187 has antibiotic properties against gram positive bacteria and fungi

Additional Information

MDL Number MFCD00151202
ChemACX X1001942-8
InChI InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
SMILES C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)c3ccc[nH]3)C)C)O[C@H]1Cc4nc5c(o4)ccc(c5C(=O)O)NC

Additional Information

GHS Pictograms
RTECS DM4676000
Handling Warning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light Protect from Moisture.

Additional Information

msds 1 A-1020, SDS.pdf
Certificate of Analysis 1 A-1020, G1328.pdf
Certificate of Analysis 2 A-1020, G1239.pdf
Certificate of Analysis 3 A-1020, A9629A.pdf

Additional Information

A23187, Free Acid

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