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Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. Does not show inherent cytotoxicity and shows no single agent activity in tumor models.
Attached are a few published references from researchers who have used our ABT-888 product. We respectfully thank them for their trust in our product. Inquire for a full reference list.
THIRST AND VOLUME, ELECTROLYTE HOMEOSTASIS: Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis, Elisabete A. Dos Santos, Annette J. Dahly-Vernon, et al., Am J Physiol Regulatory Integrative Comp Physiol, Jul 2004; 287: R58 - R68.
|Chemical Name||2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide . dihydrochloride|
|Appearance||Coloreless to white crystalline solid|
|Purity||≥98% by HPLC|
|Solubility||DMSO and H2O|
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