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Product Description
An anti-neoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis.
Potent anti-tumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Attached are a few published references from researchers who have used our Actinomycin D product. We respectfully thank them for their trust in our product. Inquire for a full reference list.
MEMBRANE TRANSPORT, STRUCTURE, FUNCTION, AND BIOGENESIS: Respiratory Syncytial Virus Inhibits Lung Epithelial Na+ Channels by Up-regulating Inducible Nitric-oxide Synthase, Weifeng Song, et al., J. Biol. Chem., Mar 2009; 284: 7294 - 7306.
ANTIVIRAL AGENTS: Heat Stress Cognate 70 Host Protein as a Potential Drug Target against Drug Resistance in Hepatitis B Virus, Yu-Ping Wang, et al., Antimicrob. Agents Chemother., May 2010; 54: 2070 - 2077.
INFLAMMATION AND IMMUNOPHARMACOLOGY: Lipopolysaccharide Induces Epithelium- and Prostaglandin E2-Dependent Relaxation of Mouse Isolated Trachea through Activation of Cyclooxygenase (COX)-1 and COX-2, Rowan W. Balzary and Thomas M. Cocks, J. Pharmacol. Exp. Ther., May 2006; 317: 806 - 812.
CELLULAR AND MOLECULAR: A Trimeric Anti-HER2/neu ScFv and Tumor Necrosis Factor- Fusion Protein Induces HER2/neu Signaling and Facilitates Repair of Injured Epithelia, Tzu-Hsuan Huang and Sherie L. Morrison, J. Pharmacol. Exp. Ther., Mar 2006; 316: 983 - 991.
MECHANISMS OF SIGNAL TRANSDUCTION: Nongenotropic, Anti-Apoptotic Signaling of 1,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes: MEDIATION BY Src, PHOSPHATIDYLINOSITOL 3-, AND JNK KINASES, Anthony M. Vertino, et al., J. Biol. Chem., Apr 2005; 280: 14130 - 14137.
Additional Information
MSDS Documentation:COA Documentation: |
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| Product Number | A-1022 |
| CAS # | CAS [50-76-0] |
| Chemical Name | Isolated from Streptomyces sp. |
| Chemical Formula | C62H86N12O16 |
| Alternative Name | Actinomycin IV, Actinomycin C1, Dactinomycin |
| Appearance | Red to orange powder |
| Merck Index | Merck Index: 12.2867.1996 |
| Molecular Weight | M.W. 1255.42 |
| Purity | Purity: >98% |
| Solubility | Soluble in DMSO: 1mg/mL, ethanol. |
| Storage Temp | +4°C |
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All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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