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Product Description
Selectively inhibits CDK2 activation leading to a potent cell cycle arrest at late G1 and S phase. Cell permeable inhibitor of JAK-2 tyrosine kinase. Does not significantly inhibit other kinases, such as Lck, Lyn, Btk, Syk or Src. Blocks IL-7 induced JAK kinase activity in T cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. Valuable tool for studying the cellular role of JAK kinases in signal transduction.
Additional Information
| Document Links | COA Documentation: |
| Product Number | A-1164 |
| CAS # | CAS [133550-30-8] |
| Chemical Name | N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide α-Cyano-(3,4-dihydroxy)-]N-benzylcinnamamide |
| Chemical Formula | C17H14N2O3 |
| Alternative Name | Tyrphostin B42, Tyrphostin AG 490 |
| Appearance | Yellow solid |
| Molecular Weight | M.W. 294.3 |
| Purity | Purity: ≥98% |
| Solubility | Soluble in DMSO (30mg/ml), DMF (40mg/ml) or 100% ethanol (10mg/ml). |
| Storage Temp | -20°C |
Notice
All products sold by A.G. Scientific are strictly for Laboratory, Bioproduction or Manufacturing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
