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Anguinomycin A

CAS: 111278-01-4 Formula: C31H44O6 MW: 512.7 Appearance: Pale yellow film Purity: >95% by HPLC
Hazardous

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A-2599 0.1 mg
$433.44
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0.5 mg
$1,517.04
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*Please inquire the availability for this product. Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumor activity in vivo against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of leptomycin B, an inhibitor of nuclear export of proteins.

Additional Information

Synonyms 5-Demethylleptomycin A, KR 2827A
Product # A-2599
CAS # 111278-01-4
Chemical Name (2E,10E,12E,16Z,18E)-6-HYDROXY-3,5,7,9,11,15,17-HEPTAMETHYL-8-OXO-19-(6-OXO-3,6-DIHYDRO-2H-PYRAN-2-YL)-2,10,12,16,18-NONADECAPENTAENOIC ACID
Formula C31H44O6
MW 512.7
Appearance Pale yellow film
Purity >95% by HPLC
Solubility Soluble in methanol, and ethanol Insoluble in DMSO
Boiling Point 714.9±60.0 °C at 760 mmHg
Storage Temp -20° C
Therapeutic Area Oncological Disorders
Use An inhibitor of nuclear export of proteins it shows antitumor activity

Additional Information

MDL Number MFCD09752704
InChI InChI=1S/C31H44O6/c1-20(16-22(3)14-15-27-12-9-13-29(34)37-27)10-8-11-21(2)17-24(5)30(35)26(7)31(36)25(6)18-23(4)19-28(32)33/h8-9,11,13-17,19-20,24-27,31,36H,10,12,18H2,1-7H3,(H,32,33)/b11-8+,15-14+,21-17+,22-16-,23-19+
SMILES O=C\1OC(/C=C/C(=C\C(C)C\C=C\C(=C\C(C(=O)C(C)C(O)C(CC(=C\C(=O)O)\C)C)C)C)C)C/C=C/1

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Anguinomycin A

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