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Anisomycin | CAS 22862-76-6 | Anti-fungal antibiotic | AG Scientific

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Anisomycin

CAS: 22862-76-6 Formula: C14H19NO4 MW: 265.3 Appearance: White powder Purity: >98% by HPLC
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A-1049 10 mg
$41.30
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50 mg
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100 mg
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500 mg
$630.00
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Anisomycin is an antifungal produced by Streptomyces griseolus. It functions by inhibiting protein synthesis in certain eukaryotic cells. Anisomycin inhibits peptidyl transferase activity in the 60s subunit of the 80s ribosome. It also increases  the phosphorylation of p70 S6 kinase α.

Anisomycin has been shown to promote apoptosis in promyelocytic leukemia cells, Jurkat cells, ventricular monocytes, and colon adenocarcinoma cells. Additionally, anisomycin is a JNK agonist and activates MAP kinases. It is used in Martin-Lewis Medium to inhibit candida albicans and aid in identification of N. gonorrhoeae. Finally, Anisomycin or Flagecidin is also an anti-protozoal agent.

 

Additional Information

Synonyms Flagecidin, SA 3097C1, PA 106, Anhydroscopin A, NSC 76712
Product # A-1049
CAS # 22862-76-6
Chemical Name 2-[(4-METHOXYPHENYL)METHYL]-3,4-PYRROLIDINEDIOL 3-ACETATE
Formula C14H19NO4
MW 265.3
Appearance White powder
Purity >98% by HPLC
Solubility Soluble in DMSO
Melting Point 139-141°C
Boiling Point 398.7±42.0 °C at 760 mmHg
Storage Temp -20° C
Therapeutic Area Psychological Disorders, Infectious Diseases

Additional Information

Merck Index 13.673.2001
MDL Number MFCD00077650
ChemACX X1000859-4
InChI InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1
SMILES CC(=O)O[C@H]1[C@@H](CN[C@H]1Cc2ccc(cc2)OC)O

Additional Information

GHS Pictograms
RTECS BZ9800000
UN #'S UN 2811
PACKING GROUP III
HAZARD CLASS 6.1 Toxic
Handling Warning.Toxic.

Additional Information

msds 1 A-1049, SDS.pdf
Certificate of Analysis 1 A-1049, G1179.pdf
Certificate of Analysis 2 A-1049, G1089.pdf
Certificate of Analysis 3 A-1049, F1203.pdf
E-Brochure Antibiotics Brochure

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Anisomycin

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