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Antibiotics

Antibiotics are essential in retaining the purity for a particular selection factor in a population of cells. Resistance to a variety of harmful antibiotics that interfere with desirable protein synthesis can be conferred through the use of cell culture products. AG Scientific has had particular success in the manufacture and supply of the following antibiotics.

  • Hygromycin B is a standard antibiotic that selects for exclusively hygromycin resistant cells. 
  • Puromycin is an antibiotic that inhibits translation via premature chain termination; it is toxic to both prokaryotic and eukaryotic cells. 

  • Blasticidin kills both eukaryotic and prokaryotic cells by inhibiting peptide bond formation. Resistance to blasticidin occurs with expression of one of three genes: bsr, bls, or BDS. 

  • G418 inhibits polypeptide synthesis in prokaryotic and eukaryotic cells and is structurally related to gentamycin. 

 

 

AG Scientific delivers quality assured antibiotics for gene selection and cell culture directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

 

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  • Product Number: L-1163

    Beta-Lactamase, E.C.3.5.2.6, penicillin amido-beta-lactam hydrolase, isolated from the organism, Bacillus cereus 569/H9 Beta Lactamase is used to destroy/remove Beta-Lactam antibiotics.

  • Product Number: R-2473

    γ-Rubromycin isolated from Streptomyces sp. consists of a

  • Product Number: A-1026

    Aphidicolin is a reversibl

  • Product Number: P-1655

    (+)-Pyripyropene A is Isolated from </

  • Product Number: L-2170

    Cell-permeable. An analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor product

  • Product Number: A-2394

    (S)-(+)-Ascochin is isolated from Ascochyta sp.

  • Product Number: D-1157

    Antibiotic which acts as an inhibitor of mammalian glucosidases I and II.

  • Product Number: A-1256

    17-AAG is an ansamycin antibiotic which acts as an anti-tumor

  • Product Number: A-1298

    A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Ge

  • Product Number: B-1265

    Boswellic acid derivative, which shows anti-tumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topo

  • Product Number: A-1130

    Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes.  Inquire

  • Product Number: C-1472

    Chloride Ionophore.  Special order item, inquire for pricing & lead time from product stock.

  • Product Number: C-2402

    5-Hydroxy-2-methyl-4-chromanone isolated from Nodulisporium

  • Product Number: A-1132

    7-Amino-Actinomycin D is a Fluorescent DNA Stain. Binds Single strand

  • Product Number: R-2002

    Product is high affinity ligand for retinoid X receptor (RXR). Able t

  • Product Number: A-2573

    *Please inquire the availability for this product. A 39183A is a rare 9,9’-MSTnthryl antibiotic related to setomimycin isolated from a strain of Streptomyces by researchers at Eli Lilly, USA, in 1981. A 39183A has broad spectrum antibiotic activity against both susceptible and resistant isolates including many anaerobic species. The patent report

  • Product Number: A-2575

    *Please inquire the availability for this product. A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. A 54556A was the original lead structure of the recently re-

  • Product Number: A-2577

    *Please inquire the availability for this product. A 54556B is an unusual depsipeptide isolated from Streptomyces hawaiiensis as antibiotics by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556B is a potent antibacterial against Gram positive and Gram negative bacteria including MRSA. A 54556B is a member of the recently re

  • Product Number: A-2579

    *Please inquire the availability for this product. A 83016F is an unusual polyene originally isolated from an unidentified actinomycete and reported in 1992. Structurally, A 83016F is related to the phenelfamycins. A 83016F exhibits activity against Gram positive bacteria.

  • Product Number: A-1020

    A23187 is a widely used ionophore. It has the ability to inc

  • Product Number: A-1128

    Used in cell activation experiments when calcium dose-response data are not required. Molar ratio Ca:Mg~1:1.Inquire for bulk pricing.

  • Product Number: A-2176

    A77 1726 physiologically active metabolite of the immunosuppressive drug leflunomide (Cat. No.1972-10, 50). A77 1726 Inhibits the activity o

  • Product Number: A-2178

    Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibiti

  • Product Number: A-2387

    Acetomycin isolated from Streptomyces ramulosus is novel antitumor ag

  • Product Number: A-1272

    Source: Produced in HEK 293 cells. The non-homologous (aa16-45) and collagen domain of human ACRP30 (aa 45-108) are fused at the N-terminus

  • Product Number: A-2585

    *Please inquire the availability for this product. Actagardin is a high molecular weight tetracyclic antibiotic produced by several species of Actinoplanes. Actagardin is an antibiotic in which the macrocyclic rings are formed by thioether, rather than disulphide, bridges. Actagardin is a potent Gram positive and Gram negative antibiotic. Actagardi

  • Product Number: A-1022

    An anti-neoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis.

  • Product Number: A-1120

    Antibiotic that demonstrates anti-tumor activity. Also unique anti-bacterial agent. Inhibitor of leucine aminopeptidase.

  • Product Number: A-1442

    Adriamycin is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces spec

  • Product Number: A-2388

  • Product Number: A-2389

     Isolated from fungus A 6239

  • Product Number: A-2390

  • Product Number: A-1286

    Membrane permeabilizing Antibiotic. Increases [32P] incorporation int

  • Product Number: A-2591

    *Please inquire the availability for this product. Alamethicin F50 is a neutral linear peptaibol complex with potent antibiotic activity, containing 20 “amino acids” with acetyl and phenylalaninol termini, produced by Trichoderma sp.. Alamethicin F50 acts an ionopohore, transporting ions through membranes and artificial lipid membranes. Alameth

  • Product Number: A-1292

    *Please inquire the availability for this product. Albofungin is a polyaromatic heterocycle containing a rare N-aminoamide, isolated from a Streptomyces species in Russia in 1959. Albofungin exhibits a broad biological profile with antibiotic, antifungal, anthelmintic and very potent antitumor activity. The mode of action of albofungin has not been

  • Product Number: A-1710

    Molds belonging to the genus Alternaria areubiquitous are common contaminants of foods & feeds. Since the molds can grow at low

  • Product Number: A-1430

    Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=10.2 µM) and Raji cell

  • Product Number: A-2185

    Amiodarone.HCl is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+

  • Product Number: A-2597

    *Please inquire the availability for this product. Amphomycin is a lipopeptide antibiotic produced by Streptomycetes and Actinoplanes, initially reported by researchers at Bristol-Myers in 1953 from Streptomyces canus. Amphomycin was marketed as a complex of closely related analogues in the 1950s and 1960s. Structure elucidation was not completed u

  • Product Number: A-1077

    A polyene anti-fungal antibiotic that non-specifically induces loss of low molecular weight substances from cells. Binds to stero

  • Product Number: A-1414

    Ampilillin Sodium Salt manufacturedto meet USP standards, assay

  • Product Number: A-2601

    *Please inquire the availability for this product. Anhydrochlortetracycline is a degradation product of chlortetracycline formed by acid-catalysed isomerisation of the dimethylamino group at C4. Anhydrochlortetracycline exhibits little antibiotic activity but its abundance is indicative of poor storage and handling of chlortetracycline.

  • Product Number: A-2603

    *Please inquire the availability for this product. Anhydroepiophiobolin A is a dehydrated analogue of ophiobolin epimerised at the C6 position. Anhydroepiophiobolin A is the major terminal degradation product of ophiobolin A and is co-produced with other ophiobolins in many Bipolaris species. Prior to 1984, references to “anhydroophiobolin” alm

  • Product Number: A-2607

    *Please inquire the availability for this product. 3-Anhydroophiobolin A is the dehydrated analogue of ophiobolin A and is a major member of the ophiobolin complex of phytotoxic metabolites produced by many species of the genus Bipolaris. Like all ophiobolins, 3-anhydroophiobolin A possesses a broad biological profile with antibacterial, antifungal

  • Product Number: A-2611

    *Please inquire the availability for this product. Anidulafungin is a semi-synthetic cyclic lipopeptide belonging to the echinocandin class that was reported in 1995 and commercially developed by Eli Lilly. Anidulafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi and is extensively refe

  • Product Number: A-1049

    Anisomycin is a pyrrolidine antibiotic, that acts as an anti-fungal

  • Product Number: A-2393

    Antibiotic PF 1052 isolated from Phoma sp. is an antibacteri

  • Product Number: A-1712

    This sterile solution is composed of penicillin (10000-12000 units/ml), streptomycin (10000-12000 ug/ml)

  • Product Number: A-1268

    Induces apoptosis, which is not prevented by the presence of bcl-2. Inhibits mitochondrial electron transport specifically between cytochrom

  • Product Number: A-2625

    Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit