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(+)-Aphidicolin Nigrospora oryzae

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(+)-Aphidicolin Nigrospora oryzae

CAS: 38966-21-1 Formula: C20H34O4 MW: 338.5 Appearance: Off-White Powder Purity: 98%
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A-1026 1 mg
$88.40
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Aphidicolin is a reversible Inhibitor of eukaryotic nuclear DNA replication. cell cycle at early S-phase.N K-independent Activation of c-Jun during Neuronal Apoptosis Induced by Multiple DNA-damaging Agents. DNA AND CHROMOSOMES: Cohesin Acetylation Promotes Sister Chromatid Cohesion Only in Association with the Replication Machinery. CELL BIOLOGY: RET Modulates Cell Adhesion via its Cleavage by Caspase in Sympathetic Neurons.

Low dose aphidicolin is an inhibitor of the DNA replicative polymerases α , δ, and ε1. Aphidicolin is a potent and specific inhibitor of B-family DNA polymerases2.

1.) http://www.jbc.org/content/290/48/28953.full.pdf+html

2.) http://nar.oxfordjournals.org/content/42/22/14013.full.pdf

Additional Information

Synonyms APH
Product # A-1026
CAS # 38966-21-1
Chemical Name (3-α,4-α,5-α,17-α)-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol
Formula C20H34O4
MW 338.5
Appearance Off-White Powder
Purity 98%
Solubility Soluble in Methanol and Ethanol
Melting Point 218-220°C
Storage Temp +4°C

Additional Information

Merck Index Merck Index: 13.734.2001
MDL Number MFCD00083214
ChemACX X1001937-7
InChI InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
SMILES C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O

Additional Information

GHS Pictograms
RTECS PB9185000
Handling Warning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure.

Additional Information

Certificate of Analysis 1 A-1026, G1069A, Alfa Aesar.pdf
Certificate of Analysis 2 A-1026, G1069.pdf
Certificate of Analysis 3 A-1026, E1352.pdf
E-Brochure Antibiotics Brochure

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(+)-Aphidicolin Nigrospora oryzae

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