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Apoptolidin

CAS: 194874-06-1 Formula: C58H96O21 MW: 1129.4 Appearance: White Lyophilisate Purity: >95% by HPLC
Hazardous

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A-2631 0.1 mg
$309.60
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0.5 mg
$1,083.60
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*Please inquire the availability for this product. Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.

Additional Information

Product # A-2631
CAS # 194874-06-1
Formula C58H96O21
MW 1129.4
Appearance White Lyophilisate
Purity >95% by HPLC
Solubility Soluble in ethanol, methanol, DMF, and DMSO
Boiling Point 1108.92 °C at 760 mmHg
Storage Temp -20°C
Therapeutic Area Oncological Disorders
Use Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase use in cancer cell lines

Additional Information

MDL Number MFCD09752711
InChI InChI=1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36-,37+,38+,39-,40+,41-,42-,43+,44-,45+,46+,47+,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1
SMILES O=C/5O[C@H]([C@@H](O)[C@]1(O)O[C@@H]([C@@H]([C@H](O)[C@H]1C)C)C[C@@H](O[C@@H]3O[C@@H](C)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](OC)C2)[C@](O)(C)C3)COC)C[C@H](OC)[C@@H](O)CC/C=C(/C=C/[C@@H](O[C@@H]4O[C@@H](C)[C@H](OC)[C@@H](O)[C@@H]4O)[C@@H](/C=C(/C=C(/C=C\5C)C)C)C)C

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Apoptolidin

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