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Apoptosis

Apoptosis is the process of programmed cell death. It is a normal and necessary phenomenon for many biological developmental processes, allowing cells to differentiate from each other and to form proper connections. It is also a critical phenomenon in aging and in healthy cell turnover; the healthy adult human body sheds tens of billions of cells each day in order to maintain homeostasis. Excessive or faulty apoptosis is associated with many human disorders such as neurodegenerative and auto-immune diseases and the proliferation of cancers. The machinery and signaling pathways that control cell life and death are key areas in human therapeutic research. A.G. Scientific is proud to offer products that can help in your research to  identify, inhibit or promote apoptosis.

A.G. Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

 

 

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(+)-Anatoxin A.Fumerate
Product Number: A-1065

Product Name Price Qty
(+)-Anatoxin A.Fumerate - 1x1mg
$190.00

Nicotinic Receptor Agonist.

** available for domestic US sales.  Product may incur dangerous good shipping charges **

Learn More

(+)-Aphidicolin, Nigrospora oryzae
Product Number: A-1026

Product Name Price Qty
(+)-Aphidicolin, Nigrospora oryzae - 1x1 mg
$55.00
(+)-Aphidicolin, Nigrospora oryzae - 1x5 mg
$185.00
(+)-Aphidicolin, Nigrospora oryzae - 1x25 mg
$670.00
Reversible Inhibitor of eukaryotic nuclear DNA replication. Learn More

(+)-Blebbistatin
Product Number: B-1285

Product Name Price Qty
(+)-Blebbistatin - 1xinquire
$0.00
The inactive enantiomer. Also useful as a negative control for the more active enantiomer (-)-Blebbistatin, B-1287. New product inquire for Learn More

(+)-Pyripyropene A, Aspergillus fumigatus
Product Number: P-1655

Product Name Price Qty
(+)-Pyripyropene A, Aspergillus fumigatus - 1x500 µg
$190.00
Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2). Learn More

(-)-Arctigenin, Arctium lappa
Product Number: A-1308

Product Name Price Qty
(-)-Arctigenin, Arctium lappa - 1x25 mg
$70.00
Lignan derivative, which shows anti-tumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic Learn More

(-)-Arctiin, Arctium lappa
Product Number: A-1306

Product Name Price Qty
(-)-Arctiin, Arctium lappa - 1x25 mg
$60.00
Lignan derivative with anti-tumor activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV Type-I Integrase and DNA Learn More

(-)-Blebbistatin
Product Number: B-1287

Product Name Price Qty
(-)-Blebbistatin - 1xinquire
$0.00
The active enantiomer that counts for the inhibitory activity toward ATPase (IC₅₀ ~2 µM) and myosin II-dependent cellular processes. N Learn More

(1S,3R)-homo-ACPD
Product Number: A-1084

Product Name Price Qty
(1S,3R)-homo-ACPD - 1x5 mg
$65.00
Selective agonist for group II mGluRs. Inquire for pricing & lead time of other ACPD products available from A.G. Scientific. Learn More

(2)-Imino-4-Methylpiperidine.Acetate Salt
Product Number: I-1009

Product Name Price Qty
(2)-Imino-4-Methylpiperidine.Acetate Salt - 1x25 mg
$90.00
A potent and selective inhibitor of inducible Nitric Oxide Synthase, iNOS / NOS II (IC50= 0.1 mM). Learn More

(E)-4-Hydroxynonenal
Product Number: H-1112

Product Name Price Qty
(E)-4-Hydroxynonenal - 1x5 mg
$126.00
Among the aldehydes formed, HNE is the major product of lipid peroxidation, and it has been suggested to play a major role in liver toxicity Learn More

(E)-Capsaicin
Product Number: C-1095

Product Name Price Qty
(E)-Capsaicin - 1x200 mg
$90.00
(E)-Capsaicin - 1x1 g
$360.00
Excitant of peripheral sensory nerves endings. Learn More

(R)-AMPA
Product Number: A-1047

Product Name Price Qty
(R)-AMPA - 1x5 mg
$185.00
Inactive enantiomer of AMPA. Also refer to A1034 (R,S)-AMPA; A1036 (S)-AMPA. Learn More

(R)-ATPA
Product Number: A-1070

Product Name Price Qty
(R)-ATPA - 1x5 mg
$195.00
(R)-ATPA - 1x10 mg
$295.00
Inactive enantiomer of ATPA at the GluR5 kainate receptor agonist. Inquire for pricing on (R,S)-ATPA. Learn More

(RS)-AMPA
Product Number: A-1034

Product Name Price Qty
(RS)-AMPA - 1x5 mg
$96.00
Potent and selective quisqualate analog that interacts with neuronal glutamate receptors. Learn More

(S)-4-Bromo-homo-ibotenic Acid
Product Number: B-1025

Product Name Price Qty
(S)-4-Bromo-homo-ibotenic Acid - 1x10 mg
$298.00
Active isomer at AMPA receptors. Acts as an agonist at native group 1 metabotropic glutamate receptors, but as an antagonist at cloned mGlu1 Learn More

(S)-AMPA
Product Number: A-1036

Product Name Price Qty
(S)-AMPA - 1x5 mg
$140.00
(S)-AMPA - 1x25 mg
$560.00
Active enantiomer of AMPA. Hygroscopic. Learn More

(S)-ATPA
Product Number: A-1072

Product Name Price Qty
(S)-ATPA - 1x5 mg
$195.00
(S)-ATPA - 1x10 mg
$295.00
Active enantiomer of ATPA. Potent and selective agonist at the GluR5 kainate receptor. Inquire for pricing on (R,S)-ATPA Learn More

(S)-Methyl-L-thiocitrulline.Dihydrochloride
Product Number: M-1012

Product Name Price Qty
(S)-Methyl-L-thiocitrulline.Dihydrochloride - 1x10 mg
$38.00
(S)-Methyl-L-thiocitrulline.Dihydrochloride - 1x50 mg
$150.00
A potent, selective inhibitor of neuronal Nitric Oxide Synthase. Learn More

(±)-1-Aminocyclopentane-cis-1,3-Dicarboxylic acid
Product Number: A-1030

Product Name Price Qty
(±)-1-Aminocyclopentane-cis-1,3-Dicarboxylic acid - 1x5 mg
$60.00
Potent NMDA agonist. Learn More

(±)-Baclofen
Product Number: B-1013

Product Name Price Qty
(±)-Baclofen - 1x1 g
$78.00
(±)-Baclofen - 1x5 g
$306.00
A GABA-b (biculline insensitive) agonist. Muscle relaxant. Learn More

(±)-BAY-K-8644
Product Number: B-1019

Product Name Price Qty
(±)-BAY-K-8644 - 1x5 mg
$165.00
A Ca2+ slow channel agonist. Learn More

(±)-Blebbistatin
Product Number: B-1289

Product Name Price Qty
(±)-Blebbistatin - 1xinquire
$0.00
A cell-permeable compound that acts as a selective, potent , and reversible inhibitor of non-moscule myosin II, Inhibits the ATPase and glid Learn More

(±)-SKF-38393.HCl
Product Number: S-1030

Product Name Price Qty
(±)-SKF-38393.HCl - 1x25 mg
$45.00
D1 Dopamine receptor agonist. Learn More

(±)-Thalidomide
Product Number: T-1020

Product Name Price Qty
(±)-Thalidomide - 1x100 mg
$102.00
(±)-Thalidomide - 1x500 mg
$410.00
Inhibits TNF-α biosynthesis. Angiogenesis inhibitor. Learn More

1-Azakenpaullone
Product Number: A-1312

Product Name Price Qty
1-Azakenpaullone - 1x1 mg
$95.00
1-Azakenpaullone - 1x5 mg
$380.00
Analog of kenpaullone acting as a potent and ATP-competitive inhibitor of GSK-3β (IC50=18nM). Displays ~100-200 fold greater selectivity on Learn More

1-Benzyl-APDC.HCL
Product Number: B-1067

Product Name Price Qty
1-Benzyl-APDC.HCL - 1x1 mg
$30.00
1-Benzyl-APDC.HCL - 1x5 mg
$120.00
mGluR6-selective ligand. Learn More

1-D-3-Deoxy-phophatidylinositol
Product Number: D-1113

Product Name Price Qty
1-D-3-Deoxy-phophatidylinositol - 1x100 μg
$30.00
1-D-3-Deoxy-phophatidylinositol - 1x1 mg
$150.00
Antimetabolite of phosphatidylinositol-3-phosphate. An inhibitor of cancer cell colony formation. Learn More

1-Deoxynojirimycin
Product Number: D-1157

Product Name Price Qty
1-Deoxynojirimycin - 1x1 mg
$31.00
1-Deoxynojirimycin - 1x5 mg
$112.00
Antibiotic which acts as an inhibitor of mammalian glucosidases I and II. Learn More

10-Hydroxycamptothecin
Product Number: H-1132

Product Name Price Qty
10-Hydroxycamptothecin - 1x inquire
$0.00
A DNA topoisomerase I inhibitor. It induces apoptosis in human breast cancer cells. Inquire for pricing and lead time. Learn More

10z-Hymenialdisine
Product Number: H-1150

Product Name Price Qty
10z-Hymenialdisine - 1x500 μg
$185.00
Potent inhibitor of mitogen-activated protein kinase kinase-1, Inhibitor of G2 DNA damage checkpoint and cyclin-dependent kinases CDK1/cycli Learn More

13-cis-Retinoic Acid
Product Number: R-1050

Product Name Price Qty
13-cis-Retinoic Acid - 1x500 mg
$115.00
13-cis-Retinoic Acid - 1x5 g
$910.00

1400W
Product Number: W-1020

Product Name Price Qty
1400W - 1x5 mg
$48.00
1400W - 1x25 mg
$188.00
A highly selective inhibitor of inducible Nitric Oxide Synthase (iNOS). Learn More

17-AAG
Product Number: A-1256

Product Name Price Qty
17-AAG - 1x500 μg
$50.00
17-AAG - 1x1 mg
$70.00
17-AAG - 1x5mg
$185.00
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Learn More

17DMAG
Product Number: A-1298

Product Name Price Qty
17DMAG - 1x1mg
$70.00
17DMAG - 1x5 mg
$185.00
A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Gelda Learn More

2-(4-Dehydroxy)coelenterazine
Product Number: C-1209

Product Name Price Qty
2-(4-Dehydroxy)coelenterazine - 1x50 μg
$110.00
Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. Shows 20 times higher lumines Learn More

2-Hydroxysaclofen
Product Number: H-1114

Product Name Price Qty
2-Hydroxysaclofen - 1x10 mg
$185.00
2-Hydroxysaclofen - 1x50 mg
$815.00
Selective antagonist of GABAB receptors, which demonstrates a higher selectivity than phaclofen. Learn More

20-Hydroxyecdysone
Product Number: H-1094

Product Name Price Qty
20-Hydroxyecdysone - 1x10 mg
$90.00
20-Hydroxyecdysone - 1x50 mg
$345.00
Most widely occurring ecdysteroid in both plant and animal species. Learn More

3-(3,4-Dimethylphenyl)-1-propyl-piperidine.Hydrochloride
Product Number: D-1153

Product Name Price Qty
3-(3,4-Dimethylphenyl)-1-propyl-piperidine.Hydrochloride - 1x5 mg
$95.00
Highly selective ligand for the D4 dopamine receptor. Learn More

3-Bromo-7-Nitroindazole
Product Number: B-1001

Product Name Price Qty
3-Bromo-7-Nitroindazole - 1x25 mg
$50.00
3-Bromo-7-Nitroindazole - 1x50 mg
$80.00
A potent inhibitor of rat cerebellar Nitric Oxide Synthase (NOS). More potent inhibitor than 7-nitroindazole. Learn More

3-F-Deoxy-Ins(1,4,5)P3. 6Na
Product Number: D-1109

Product Name Price Qty
3-F-Deoxy-Ins(1,4,5)P3. 6Na - 1x100 ug
$40.00
Equal to Ins(1,4,5)P3 in releasing intracellular calcium. The 3-position is blocked by fluorine so it can not be converted to Ins(1,3,4,5)P4 Learn More

3-O-Acetyl-11-keto-beta-boswellic acid, Boswellia serrata
Product Number: B-1265

Product Name Price Qty
3-O-Acetyl-11-keto-beta-boswellic acid, Boswellia serrata - 1x5 mg
$130.00
Boswellic acid derivative, which shows anti-tumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topo Learn More

3-O-Acetyl-beta-boswellic acid, Boswellia sp.
Product Number: B-1263

Product Name Price Qty
3-O-Acetyl-beta-boswellic acid, Boswellia sp. - 1x1 mg
$45.00
3-O-Acetyl-beta-boswellic acid, Boswellia sp. - 1x5 mg
$178.00
Boswellic acid derivative, which shows anti-tumor and anti-inflammatory activities. Potent non-redox, non-competitive 5-lipoxygenase and top Learn More

4-Bromo-A23187
Product Number: A-1130

Product Name Price Qty
4-Bromo-A23187 - 1x1 mg
$80.00
4-Bromo-A23187 - 1x5 mg
$240.00
Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes. Learn More

4AF DA
Product Number: A-1140

Product Name Price Qty
4AF DA - 1x1 mg
$210.00
Negative control compound for the fluorescent probes DAF-2 and DAF-2 DA. Learn More

7-Amino-Actinomycin D
Product Number: A-1132

Product Name Price Qty
7-Amino-Actinomycin D - 1x1 mg
$70.00
7-Amino-Actinomycin D - 1x5 mg
$240.00
Fluorescent DNA Stain. Binds Single stranded DNA. Useful tool in determining apoptosis. Learn More

7-Nitroindazole
Product Number: N-1011

Product Name Price Qty
7-Nitroindazole - 1x100 mg
$50.00
An inhibitor of Nitric Oxide Synthase (NOS). It has a selectivity for brain NOS. Learn More

7-Nitroindazole.Monosodium Salt
Product Number: N-1013

Product Name Price Qty
7-Nitroindazole.Monosodium Salt - 1x25 mg
$75.00
7-Nitroindazole.Monosodium Salt - 1x100 mg
$225.00
A readily soluble inhibitor of Nitric Oxide Synthase (NOS). It has a selectivity for brain NOS. Learn More

9-cis-Retinoic Acid
Product Number: R-2002

Product Name Price Qty
9-cis-Retinoic Acid - 1x5 mg
$96.00
9-cis-Retinoic Acid - 1x25 mg
$480.00
Product is high affinity ligand for retinoid X receptor (RXR). Able to destablize VDR=RXR heterodimer-DNA complex. Learn More

A23187, Free Acid
Product Number: A-1020

Product Name Price Qty
A23187, Free Acid - 1x5 mg
$50.00
A23187, Free Acid - 1x10 mg
$75.00
A23187, Free Acid - 1x50 mg
$320.00
A widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intra Learn More

A23187, Mixed Calcium-Magnesium Salt
Product Number: A-1128

Product Name Price Qty
A23187, Mixed Calcium-Magnesium Salt - 1x5 mg
$52.50
A23187, Mixed Calcium-Magnesium Salt - 1x10 mg
$84.00
Used in cell activation experiments when calcium dose-response data are not required. Molar ratio Ca:Mg~1:1. Learn More

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