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Annexin V

 In healthy cells, phosphatidylserine (PS) is predominantly located along the cytoplasmic surface of the plasma membrane. Upon initiation of apoptosis, PS loses its asymmetric distribution in the phospholipid bilayer and is translocated to the extracellular membrane where it can be detected with fluorescently labeled Annexin V. In early stage of apoptosis, the plasma membrane excludes viability dyes such as propidium iodide (PI) and 7-AAD. These cells will display only Annexin V staining but not a viability dye(PI/7AAD negative). However, in the late stage of apoptosis, the cell membrane loses integrity so Annexin V could bind to cytosolic PS, as well as cell update of a viability dye (PI/7AAD positive). Annexin V staining, paired with 7-AAD or PI is widely used to identify apoptotic stages by flow cytometry.

AG Scientific can ship FedEx directly to your lab, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

 

FREE REVIEW ARTICLES

 

  1. Annexin V (APC Labelled), Human, Recombinant

    Annexin V (APC Labelled), Human, Recombinant

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-1086 20 Tests
    $112.04
    100 Tests
    $323.33
  2. Annexin V (FITC) (human) (recombinant)

    Annexin V (FITC) (human) (recombinant)

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-1244 100 Tests
    $203.71
    300 Tests
    $446.05