![Cycloheximide | CAS [66-81-9], Antibiotics, M.W. 281.3, Cycloheximide is antibiotic which acts as an inhibitor of protein synthesis in eukaryotes but not prokaryotes. Cycloheximide's selectivity makes it active against yeast & fungi but tolerated by mos](http://www.agscientific.com/media/catalog/product/cache/1/thumbnail/56x/5e06319eda06f020e43594a9c230972d/C/-/C-1189_250x500.jpg "Cycloheximide | CAS [66-81-9], Antibiotics, M.W. 281.3, Cycloheximide is antibiotic which acts as an inhibitor of protein synthesis in eukaryotes but not prokaryotes. Cycloheximide's selectivity makes it active against yeast & fungi but tolerated by mos")
![Cycloheximide, Actidione | CAS [66-81-9] | Useful Antibiotic vs. eukaryotes. Cycloheximide offered by A.G. Scientific.](http://www.agscientific.com/media/catalog/product/cache/1/thumbnail/56x/5e06319eda06f020e43594a9c230972d/f/i/file_4_26.png "Cycloheximide, Actidione | CAS [66-81-9] | Useful Antibiotic vs. eukaryotes. Cycloheximide offered by A.G. Scientific.")
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Product Description
Cycloheximide is an antibiotic produced by Streptomyces griseus, and acts as an inhibitor of protein synthesis in eukaryotes but not prokaryotes. Cycloheximide's selectivity makes it active against yeast and fungi but tolerated by most bacteria.
Cycloheximide is also used to induce apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types.
Additionally, plant researchers have shown it to stimulate ethylene production in fruit and leaves.
In molecular biology applications, it is used in the selection of wild type CAN1, CYH2 and LYS2 genes.
6. Role of Glycogen Synthase Kinase 3ß in Rapamycin-Mediated Cell Cycle Regulation and Chemosensitivity
Cycloheximide is also used to induce apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types.
Attached are a few published references from researchers who have used our Cycloheximide product. We respectfully thank them for their trust in our product. Inquire for a full reference list.
Additionally, plant researchers have shown it to stimulate ethylene production in fruit and leaves.
In molecular biology applications, it is used in the selection of wild type CAN1, CYH2 and LYS2 genes.
Seeking published researchers utilizing our Cycloheximide product? Hit the hot link for the full paper.
1. TORC1 controls degradation of the transcription factor Stp1, a key effector of the SPS amino-acid-sensing pathway in Saccharomyces cerevisiae, Chun-Shik Shin, Sun Young Kim, et al, Jun 2009; 122: 2089 - 2099.
2. IL-27 Activates Human Monocytes via STAT1 and Suppresses IL-10 Production but the Inflammatory Functions of IL-27 Are Abrogated by TLRs and p38, George D. Kalliolias and Lionel B. Ivashkiv, May 2008; 180: 6325 - 6333.
3. Involvement of Secretory and Endosomal Compartments in Presentation of an Exogenous Self-Glycolipid to Type II NKT Cells, Keshab Chandra Roy, Igor Maricic, et al, Mar 2008; 180: 2942 - 2950.
4. Rapid Turnover of the mTOR Complex 1 (mTORC1) Repressor REDD1 and Activation of mTORC1 Signaling following Inhibition of Protein Synthesis, Scot R. Kimball, A. N. Dang Do, et al, Feb 2008; 283: 3465 - 3475.
5. Insulin-Like Growth Factor Binding Protein-3 Leads to Insulin Resistance in Adipocytes, Sophie S. Y. Chan, Stephen M. Twigg, et al, Dec 2005; 90: 6588 - 6595.
6. Role of Glycogen Synthase Kinase 3ß in Rapamycin-Mediated Cell Cycle Regulation and Chemosensitivity
JinJiang Dong, Junying Peng, Haixia Zhang, et al, Mar 2005; 65: 1961 - 1972.
Additional Information
MSDS Documentation:COA Documentation: |
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| Product Number | C-1189 |
| CAS # | CAS [66-81-9] |
| Chemical Formula | C15H23NO4 |
| Alternative Name | Actidione, Naramycin A, NSC-185, U-4527 |
| Appearance | White Solid |
| Molecular Weight | M.W. 281.3 |
| Preparation | Store solutions at -20C. |
| Purity | Purity: >98% |
| RTECS | RTECS: MA4375000 |
| Solubility | Soluble in Chloroform, Ethanol and Methanol. |
| Storage Temp | +4°C |
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