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Product Description
Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC₅₀ = 58 nM (Akt1), 210 nM (Akt2) and 2.12 µM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50 µM).
Additional Information
| Product Number | A-1714 |
| CAS # | 612847-09-3 |
| Chemical Name | 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2 |
| Chemical Formula | C34H29N7 |
| Appearance | Light yellow solid |
| Molecular Weight | 551.65 |
| Purity | ≥97% by HPLC |
| Solubility | DMSO |
| Storage Temp | -20°C |
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