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Apoptosis

Apoptosis is the process of programmed cell death. It is a normal and necessary phenomenon for many biological developmental processes, allowing cells to differentiate from each other and to form proper connections. It is also a critical phenomenon in aging and in healthy cell turnover; the healthy adult human body sheds tens of billions of cells each day in order to maintain homeostasis. Excessive or faulty apoptosis is associated with many human disorders such as neurodegenerative and auto-immune diseases and the proliferation of cancers. The machinery and signaling pathways that control cell life and death are key areas in human therapeutic research. A.G. Scientific is proud to offer products that can identify, inhibit or promote apoptosis.

A.G. Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

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(+)-Aphidicolin, Nigrospora oryzae
Product Number: A-1026

Product Name Price Qty
(+)-Aphidicolin, Nigrospora oryzae - 1x1 mg
$55.00
(+)-Aphidicolin, Nigrospora oryzae - 1x5 mg
$185.00
(+)-Aphidicolin, Nigrospora oryzae - 1x25 mg
$670.00
Reversible Inhibitor of eukaryotic nuclear DNA replication. Learn More

(+)-Blebbistatin
Product Number: B-1285

Product Name Price Qty
(+)-Blebbistatin - 1xinquire
$0.00
The inactive enantiomer. Also useful as a negative control for the more active enantiomer (-)-Blebbistatin, B-1287. New product inquire for Learn More

(-)-Arctigenin, Arctium lappa
Product Number: A-1308

Product Name Price Qty
(-)-Arctigenin, Arctium lappa - 1x25 mg
$70.00
Lignan derivative, which shows anti-tumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic Learn More

(-)-Arctiin, Arctium lappa
Product Number: A-1306

Product Name Price Qty
(-)-Arctiin, Arctium lappa - 1x25 mg
$60.00
Lignan derivative with anti-tumor activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV Type-I Integrase and DNA Learn More

(-)-Blebbistatin
Product Number: B-1287

Product Name Price Qty
(-)-Blebbistatin - 1xinquire
$0.00
The active enantiomer that counts for the inhibitory activity toward ATPase (IC₅₀ ~2 µM) and myosin II-dependent cellular processes. N Learn More

(±)-Blebbistatin
Product Number: B-1289

Product Name Price Qty
(±)-Blebbistatin - 1xinquire
$0.00
A cell-permeable compound that acts as a selective, potent , and reversible inhibitor of non-moscule myosin II, Inhibits the ATPase and glid Learn More

(±)-Thalidomide
Product Number: T-1020

Product Name Price Qty
(±)-Thalidomide - 1x100 mg
$102.00
(±)-Thalidomide - 1x500 mg
$410.00
Inhibits TNF-α biosynthesis. Angiogenesis inhibitor. Learn More

1-Azakenpaullone
Product Number: A-1312

Product Name Price Qty
1-Azakenpaullone - 1x1 mg
$95.00
1-Azakenpaullone - 1x5 mg
$380.00
Analog of kenpaullone acting as a potent and ATP-competitive inhibitor of GSK-3β (IC50=18nM). Displays ~100-200 fold greater selectivity on Learn More

10-Hydroxycamptothecin
Product Number: H-1132

Product Name Price Qty
10-Hydroxycamptothecin - 1x inquire
$0.00
A DNA topoisomerase I inhibitor. It induces apoptosis in human breast cancer cells. Inquire for pricing and lead time. Learn More

10z-Hymenialdisine
Product Number: H-1150

Product Name Price Qty
10z-Hymenialdisine - 1x500 μg
$185.00
Potent inhibitor of mitogen-activated protein kinase kinase-1, Inhibitor of G2 DNA damage checkpoint and cyclin-dependent kinases CDK1/cycli Learn More

13-cis-Retinoic Acid
Product Number: R-1050

Product Name Price Qty
13-cis-Retinoic Acid - 1x500 mg
$115.00
13-cis-Retinoic Acid - 1x5 g
$910.00

17-AAG
Product Number: A-1256

Product Name Price Qty
17-AAG - 1x500 μg
$50.00
17-AAG - 1x1 mg
$70.00
17-AAG - 1x5mg
$185.00
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Learn More

17DMAG
Product Number: A-1298

Product Name Price Qty
17DMAG - 1x1mg
$70.00
17DMAG - 1x5 mg
$185.00
A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Gelda Learn More

20-Hydroxyecdysone
Product Number: H-1094

Product Name Price Qty
20-Hydroxyecdysone - 1x10 mg
$90.00
20-Hydroxyecdysone - 1x50 mg
$345.00
Most widely occurring ecdysteroid in both plant and animal species. Learn More

3-O-Acetyl-11-keto-beta-boswellic acid, Boswellia serrata
Product Number: B-1265

Product Name Price Qty
3-O-Acetyl-11-keto-beta-boswellic acid, Boswellia serrata - 1x5 mg
$130.00
Boswellic acid derivative, which shows anti-tumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topo Learn More

3-O-Acetyl-beta-boswellic acid, Boswellia sp.
Product Number: B-1263

Product Name Price Qty
3-O-Acetyl-beta-boswellic acid, Boswellia sp. - 1x1 mg
$45.00
3-O-Acetyl-beta-boswellic acid, Boswellia sp. - 1x5 mg
$178.00
Boswellic acid derivative, which shows anti-tumor and anti-inflammatory activities. Potent non-redox, non-competitive 5-lipoxygenase and top Learn More

4-Bromo-A23187
Product Number: A-1130

Product Name Price Qty
4-Bromo-A23187 - 1x1 mg
$80.00
4-Bromo-A23187 - 1x5 mg
$240.00
Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes. Learn More

7-Amino-Actinomycin D
Product Number: A-1132

Product Name Price Qty
7-Amino-Actinomycin D - 1x1 mg
$70.00
7-Amino-Actinomycin D - 1x5 mg
$240.00
Fluorescent DNA Stain. Binds Single stranded DNA. Useful tool in determining apoptosis. Learn More

A23187, Free Acid
Product Number: A-1020

Product Name Price Qty
A23187, Free Acid - 1x5 mg
$50.00
A23187, Free Acid - 1x10 mg
$75.00
A23187, Free Acid - 1x50 mg
$320.00
A widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intra Learn More

A23187, Mixed Calcium-Magnesium Salt
Product Number: A-1128

Product Name Price Qty
A23187, Mixed Calcium-Magnesium Salt - 1x5 mg
$52.50
A23187, Mixed Calcium-Magnesium Salt - 1x10 mg
$84.00
Used in cell activation experiments when calcium dose-response data are not required. Molar ratio Ca:Mg~1:1. Learn More

Ac-ESMD-CHO
Product Number: G-1073

Product Name Price Qty
Ac-ESMD-CHO - 1x1 mg
$83.00
Ac-ESMD-CHO - 1x5 mg
$320.00
Reversible Inhibitor of granzyme B and caspase-8. Inhibits also caspase-6 and -10. This peptide sequence corresponds to one of the cleavage Learn More

Ac-IETD-AFC, Granzyme B Substrate
Product Number: C-1145

Product Name Price Qty
Ac-IETD-AFC, Granzyme B Substrate - 1x5 mg
$140.00
Ac-IETD-AFC, Granzyme B Substrate - 1x10 mg
$240.00
Fluorogenic substrate for caspase-8, caspase-3 processing enzyme and Granzyme B. Also substrate for Caspase-10. Reported AFC excitation max Learn More

Ac-IETD-AMC
Product Number: G-1081

Product Name Price Qty
Ac-IETD-AMC - 1x1 mg
$42.00
Ac-IETD-AMC - 1x5 mg
$120.00
Fluorogenic substrate for caspase-8 and granzyme B. Also substrate for caspase-10. Peptide content: 70-90% Learn More

Ac-IETD-CHO
Product Number: G-1071

Product Name Price Qty
Ac-IETD-CHO - 1x1 mg
$62.00
Ac-IETD-CHO - 1x5 mg
$240.00
Reversible inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10. Peptide content: 70-90% Learn More

Ac-IETD-pNA
Product Number: G-1085

Product Name Price Qty
Ac-IETD-pNA - 1x1 mg
$25.00
Ac-IETD-pNA - 1x5 mg
$90.00
Chromogenic substrate for granzyme B, caspase-8. Also substrate for caspase-10. Peptide Content: 70-90% Learn More

Actinomycin D, Streptomyces sp.
Product Number: A-1022

Product Name Price Qty
Actinomycin D, Streptomyces sp. - 1x5 mg
$45.00
Actinomycin D, Streptomyces sp. - 1x10 mg
$70.00
Actinomycin D, Streptomyces sp. - 1x25 mg
$155.00
Actinomycin D, Streptomyces sp. - 1x100 mg
$455.00
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymera Learn More

Adenophostin A
Product Number: A-1126

Product Name Price Qty
Adenophostin A - 1x50 μg
$285.00
A potent Inositol-1,4,5-trisphosphate (IP3) receptor agonist. 10 times more potent than IP3. Learn More

AG 1007
Product Number: A-1180

Product Name Price Qty
AG 1007 - 1x1 mg
$50.00
AG 1007 - 1x5 mg
$148.00

AG 1024
Product Number: A-1178

Product Name Price Qty
AG 1024 - 1x1 mg
$65.00
AG 1024 - 1x5 mg
$248.00
An inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Learn More

AG 1112
Product Number: A-1176

Product Name Price Qty
AG 1112 - 1x1 mg
$50.00
AG 1112 - 1x5 mg
$148.00

AG 126
Product Number: A-1208

Product Name Price Qty
AG 126 - 1x5 mg
$75.00

Reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM.  At 100uM does not inhibi Learn More

AG 1288
Product Number: A-1192

Product Name Price Qty
AG 1288 - 1x10 mg
$71.00
AG 1288 - 1x50 mg
$275.00

Tyrosine kinase inhibitor reported to block TNFα induced cytotoxicity.  Also blocks glucocorticoid-induced COX-2 activity in human amn Learn More

AG 1295
Product Number: A-1188

Product Name Price Qty
AG 1295 - 1x1 mg
$30.00
AG 1295 - 1x5 mg
$80.00

AG 1296
Product Number: A-1174

Product Name Price Qty
AG 1296 - 1x5 mg
$103.00
Selective inhibitor of platelet-derived growth factor (PDGF) receptor protein. Learn More

AG 1385
Product Number: A-1170

Product Name Price Qty
AG 1385 - 1x1 mg
$55.00
AG 1385 - 1x5 mg
$158.00

AG 1433
Product Number: A-1168

Product Name Price Qty
AG 1433 - 1x1 mg
$35.00
AG 1433 - 1x5 mg
$98.00
Potent and specific inhibitor of PDGF-b receptor kinase (IC50 = 5.0 μm) and Flk-1/KDR (IC50 = 9.3 μm). Also acts as an angiogenesis inhibi Learn More

AG 1478
Product Number: A-1296

Product Name Price Qty
AG 1478 - 1x1 mg
$30.00
AG 1478 - 1x5 mg
$80.00

AG 1517, PD 153035
Product Number: P-1237

Product Name Price Qty
AG 1517, PD 153035 - 1x5 mg
$84.00
AG 1517, PD 153035 - 1x25 mg
$328.00
A tyrosine kinase inhibitor. Also inhibits Epidermal Growth Factor. Learn More

AG 183
Product Number: A-1206

Product Name Price Qty
AG 183 - 1x5 mg
$55.00
AG 183 - 1x25 mg
$158.00

AG 34
Product Number: A-1212

Product Name Price Qty
AG 34 - 1x1 mg
$35.00
AG 34 - 1x5 mg
$98.00

AG 370
Product Number: A-1186

Product Name Price Qty
AG 370 - 1x2 mg
$90.00
AG 370 - 1x10 mg
$365.00
Inhibitor of platelet derived growth factor (PDGF) autophosphorylation and PDGF-induced mitogenesis. Learn More

AG 490
Product Number: A-1164

Product Name Price Qty
AG 490 - 1x10 mg
$70.00
AG 490 - 1x50 mg
$285.00
Selectively inhibits CDK2 activation leading to a potent cell cycle arrest at late G1 and S phase. Cell permeable inhibitor of JAK-2 tyrosin Learn More

AG 494
Product Number: A-1166

Product Name Price Qty
AG 494 - 1x10 mg
$60.00
AG 494 - 1x50 mg
$245.00
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.  Potent inhibitor of EGF receptor autophosphorylation (IC< Learn More

AG 527
Product Number: A-1214

Product Name Price Qty
AG 527 - 1x5 mg
$25.00
AG 527 - 1x25 mg
$90.00

AG 528
Product Number: A-1204

Product Name Price Qty
AG 528 - 1x5 mg
$30.00
AG 528 - 1x25 mg
$85.00

AG 537
Product Number: A-1202

Product Name Price Qty
AG 537 - 1x5 mg
$65.00
AG 537 - 1x25 mg
$189.00
Competitively inhibits EGF receptor kinase autophosphorylation. Learn More

AG 658
Product Number: A-1200

Product Name Price Qty
AG 658 - 1x1 mg
$30.00
AG 658 - 1x5 mg
$95.00

AG 698
Product Number: A-1218

Product Name Price Qty
AG 698 - 1x5 mg
$30.00
AG 698 - 1x25 mg
$85.00

AG 808
Product Number: A-1184

Product Name Price Qty
AG 808 - 1x5 mg
$45.00
AG 808 - 1x25 mg
$128.00

AG 82
Product Number: A-1210

Product Name Price Qty
AG 82 - 1x5 mg
$35.00
AG 82 - 1x25 mg
$100.00

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