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Autophagy

Autophagy (literally “self-eating”) and apoptosis (programmed cell death) control the turnover of various cytoplasmic constituents within eukaryotic cells, and of cells within organisms, respectively. Autophagy is triggered under certain hostile conditions such as nutrient starvation, hypoxia, immune and hormone stimulation.  Generally autophagy blocks the induction of apoptosis, and apoptosis-associated caspase activation shuts off the autophagic process. However, in special cases, autophagy or autophagy-relevant proteins may help to induce apoptosis or necrosis. The interaction between autophagy and cell death pathways influences the normal clearance of dying cells, as well as immune recognition of dead cell antigens. Therefore, the disruption of the relationship between autophagy and apoptosis has important pathophysiological consequences. Many researches show that malfunctions in this process are related to diseases such as cancer, neurodegeneration, diabetes, autoimmune and cardiovascular disease.

AG Scientific can ship FedEx directly to your lab, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

  1. Amiodarone Hydrochloride

    Amiodarone Hydrochloride

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-2185 19774-82-4 100 mg
    $69.36
    500 mg
    $272.11
  2. Bafilomycin A1

    Bafilomycin A1

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    B-1183 88899-55-2 1 mg
    $187.81
  3. Bafilomycin B1 | CAS 88899-56-3 | Inhibits  H+-ATPases natural extract

    Bafilomycin B1

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    B-1185 88899-56-3 1 mg
    $224.09
  4. Bafilomycin B2

    Bafilomycin B2

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    B-1245 88907-48-6 Inquire 50 mg
    $0.00
  5. Chloroquine Diphosphate

    Chloroquine Diphosphate

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    C-2265 50-63-5 100 mg
    $70.00
    500 mg
    $220.00
  6. Hydroxychloroquine sulfate

    Hydroxychloroquine sulfate

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    H-2451 747-36-4 10 mg
    $154.73
  7. LY294002 EZSolution™

    LY294002 EZSolution™

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    E-2312 154447-36-6 5 mg
    $85.37
  8. Niclosamide

    Niclosamide

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    N-1219 50-65-7 100 mg
    $80.03
    500 mg
    $282.78
  9. CAS 129-56-6 SP-600125 is a potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK)

    SP600125

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    S-2022 129-56-6 5 mg
    $44.81
    25 mg
    $141.93
  10. U0126

    U0126

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    U-1026 109522-58-2 1 mg
    $66.16
    5 mg
    $243.30
  11. Verruculogen| CAS [ 12771-72-1 ] | Mycotoxin Lowers GABA levels in CNS | Verruculogen decreases GABA levels in CNS.  A.G.Scientific

    Verruculogen, Penicillium verruculosum

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    V-1000 12771-72-1 1 mg
    $101.37
    5 mg
    $346.80
  12. Wortmannin

    Wortmannin

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    W-1022 19545-26-7 1 mg
    $53.35
    5 mg
    $160.06
    25 mg
    $624.25