Cathepsin Inhibitors

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Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein, Vivian Y. H. Hook, Mark Kindy, et al. Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein. J. Biol. Chem, 2008; 283: 7745 - 7753.

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry, Graham Simmons, Dhaval N. Gosalia, et al. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. PNAS, 2005; 102: 11876 - 11881.

A Cathepsin K Inhibitor Reduces Breast Cancer–Induced Osteolysis and Skeletal Tumor Burden, Céline Le Gall, Akeila Bellahcène, et al. A Cathepsin K Inhibitor Reduces Breast Cancer–Induced Osteolysis and Skeletal Tumor Burden. Cancer Res, 2007; 67: 9894 - 9902.

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Product Number	A-1413
CAS #	CAS[37682-72-7]
Chemical Name	[(S)-1-Carboxy-2-Phenylethyl]-Carbamoyl-Arg-Val-Argininal.
Chemical Formula	C₂₇H₄₄N₁₀O₆.HCl
Appearance	White to off-white solid.
Molecular Weight	M.W.641.16
Solubility	H2O (10 mg/ml), Methanol, Ethanol
Storage Temp	+4°C

COA Documentation: A-1413, B1600 Antipain.Hydrochloride Product Number: A-1413
Price	Price	Qty	Add to Cart
1x5 mg	$60.00
1x10 mg	$118.00

Product Number	C-2213
CAS #	N/A
Chemical Name	Z-LLY-FMK, Calpain Inhibitor(fluoromethylketone)
Chemical Formula	C₃₀H₄₀FN₃O₆
Appearance	Liquid
Molecular Weight	557.7
Purity	>95% by HPLC
Solubility	N/A
Storage Temp	-20°C

Calpain Inhibitor Z-LLY-FMK Product Number: C-2213
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1x20 l (10 mM)	$120.00

Product Number	C-2226
CAS #	N/A
Chemical Name	Z-YVAD-FMK, Caspase-1 Inhibitor (fluoromethylketone)
Chemical Formula	C₃₁H₃₉FN₄O₉
Appearance	Liquid
Molecular Weight	630.7
Purity	>99% by HPLC
Solubility	N/A
Storage Temp	-20°C

Caspase-1 Inhibitor Z-YVAD-FMK Product Number: C-2226
Price	Price	Qty	Add to Cart
1x100 l	$120.00
1x20 l	$120.00

Product Number	C-2259
CAS #	N/A
Chemical Name	Z-FF-FMK, Cathepsin B&L Inhibitor(fluoromethylketone)
Chemical Formula	C₂₇H₂₇FN₂O₄
Appearance	Liquid
Molecular Weight	462.5
Purity	>95% by HPLC
Solubility	N/A
Storage Temp	-20°C

Cathepsin B&L Inhibitor Z-Phe-Phe-FMK Product Number: C-2259
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1x20 l (10 mM)	$165.00

Cathepsin G Inhibitor Product Number: C-2260
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1x1 mg	$165.00

Product Number	E-2030
CAS #	CAS[66701-25-5]
Chemical Name	trans-Epoxysucciny-L-leucyl-amido(4-guanidino) butane; (L-3-trans-Carboxyoxiran-2-Carbonyl)-L-Leucyl-Admat
Chemical Formula	C₁₅H₂₇N₅O₅
Alternative Name	E64
Appearance	White Solid
Molecular Weight	M.W. 357.4
Purity	Purity:>99%
Solubility	DMSO (25mg/ml) and H20 (20mg/ml)
Storage Temp	-20°C

MSDS Documentation: E-2030, E-64, MSDS COA Documentation: E-2030, B1549 E-2030, B1682 E-2030, C1175 E-2030, C1306 E-64 Product Number: E-2030
Price	Price	Qty	Add to Cart
1x5 mg	$45.00
1x25 mg	$180.00

COA Documentation: G-1035, D1112 G-1035, C1100 G-1035, C1308 G-1035, D1057 G-418.Sulfate, Sterile-Filtered Solution Product Number: G-1035
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1x10 ml	$34.00
1x50 ml	$120.00
5x 10 ml	$135.00
1x100 ml	$225.00

Product Number	L-1165
CAS #	CAS [103476-89-7]
Chemical Name	Ac-Leu-Leu-Arginal
Chemical Formula	C₂₀H₃₈N₆O₄.0.5 H₂SO₄
Alternative Name	Ac-Leu-Leu-Arginal, Leupeptin
Appearance	White Solid
Molecular Weight	M.W. 475.6
Purity	Purity: Three tautomeric isomers in solution
Solubility	Soluble in H20 (50mg/ml). Effective concentration 10-100uM
Storage Temp	-20°C

MSDS Documentation: L-1165, MSDS.pdf COA Documentation: L-1165, C1165E L-1165, D1017A L-1165, C1165D L-1165, D1017 Leupeptin, Hemisulfate Product Number: L-1165
Price	Price	Qty	Add to Cart
1x5 mg	$22.00
1x25 mg	$93.50
1x100 mg	$330.00

Product Number	P-1519
CAS #	CAS[26305-03-3]
Chemical Name	Isovaleryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA (AHMHA=(3S, 4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
Chemical Formula	C₃₄H₆₃N₅O₉
Alternative Name	Pepstatin A \| CAS 26305-03-3
Appearance	White Solid.
Molecular Weight	M.W.685.9
Purity	Purity:≥98%
Solubility	DMSO (5 mg/ml) or Methanol (1 mg/ml). Effective concentration 1µM
Storage Temp	+4°C

COA Documentation: P-1519, B1844 P-1519, C1049 P-1519, C1311 P-1519, C1311A P-1519, C1311B Pepstatin A \| Inhibitor of aspartic proteases Product Number: P-1519
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1x1+ GM	$0.00
1x5 mg	$33.00
1x25 mg	$95.00

Product Number	P-1548
Appearance	Clear Colorless Solution
Purity	Suitable for use as Protease Inhibitors.
Solubility	Supplied as a liquid in 1 ml DMSO. Add to water, aqueous buffer or directly to extraction media.
Storage Temp	-20°C

COA Documentation: P-1548, D1115 P-1548, B1523 P-1548, C1312 Protease Inhibitor Cocktail VIII Product Number: P-1548
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1x1 ml	$54.00

Product Number	Z-2486
CAS #	105637-38-5
Chemical Name	Benzyloxycarbonyl-Phe-Ala-Fluoromethylketone; Z-Phe-Ala fluoromethyl ketone; Z-Phe-Ala-FMK
Chemical Formula	C₂₁H₂₃N₂O₄F
Appearance	White to off-white solid
Molecular Weight	386.42
Purity	≥95% by HPLC
Solubility	DMSO (20 mM)
Storage Temp	-20°C

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