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Granzymes

Granzymes (granule-secreted enzymes) are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They trigger programmed cell death in the target cell. Its important role is to eliminate cells that have become cancerous or are infected with viruses or bacteria in the immune defense.

Granzyme B activates caspase (especially caspase-3) and also cleaves the factors like ICAD. It also cleaves many of the proteins lick Bid, which recruits the proteins Bax and Bak to change the membrane permeability of the mitochondria, causing the release of cytochrome c responsible for apoptosis in the absence of caspase activity. Granzyme A is also an abundant granzyme released by cytotoxic T cells and is important in cytotoxic T cell induced apoptosis, activating caspase independent pathways.

AG Scientific can ship FedEx directly to your lab, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

  1. Ac-ESMD-CHO

    Ac-ESMD-CHO

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    G-1073 1 mg
    $61.90
    5 mg
    $234.76
  2. Ac-IETD-AMC

    Ac-IETD-AMC

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    G-1081 1 mg
    $44.81
    5 mg
    $128.05
  3. Ac-IETD-CHO

    Ac-IETD-CHO

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    G-1071 191338-86-0 1 mg
    $105.64
  4. Ac-IETD-pNA

    Ac-IETD-pNA

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    G-1085 1 mg
    $29.88
    5 mg
    $106.71
  5. EZSolution Q-VD-OPh

    EZSolution Q-VD-OPh

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    E-2317 1135695-98-5 1 mg
    $208.08
  6. EZSolution Q-VD-OPh, Negative Control

    EZSolution Q-VD-OPh, Negative Control

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    E-2318 1 mg
    $176.07
  7. MDL-12330A Hydrochloride

    MDL-12330A Hydrochloride

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    M-1026 40297-09-4 1 mg
    $69.36
  8. Nafamostat Mesylate

    Nafamostat Mesylate

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    F-1160 82956-11-4 10 mg
    $74.70
    50 mg
    $304.12
  9. Z-IE(OMe)TD(OMe)-FMK

    Z-IE(OMe)TD(OMe)-FMK

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    G-1077 1 mg
    $234.76
    5 mg
    $757.63
  10. Z-IETD-pNA

    Z-IETD-pNA

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    G-1083 1 mg
    $23.47
    5 mg
    $88.57