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p53 is the tumor suppressor that regulates the expression of p53 upregulated modulator of apoptosis (PUMA). PUMA is involved in p53-dependent and –independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. P53 is a major orchestrator of the cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, senescence, DNA repair and genetic stability. After activation, PUMA interacts with the multidomain Bcl-2 family members to signal apoptosis to the mitochondria by inducing outer membrane permeabilization.
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FREE REVIEW ARTICLES
- p53-based cancer therapies: is defective p53 the Achilles heel of the tumor?, Aime A. Levesque and Alan Eastman. p53-based cancer therapies: is defective p53 the Achilles heel of the tumor? Carcinogenesis, 2007; 28: 13 - 20.
- p53 and its mutants in tumor cell migration and invasion, Patricia A. J. Muller, Karen H. Vousden, et al. p53 and its mutants in tumor cell migration and invasion. J. Cell Biol, 2011; 192: 209 - 218.
- p53 at a glance, Colleen A. Brady and Laura D. Attardi. p53 at a glance. J. Cell Sci, 2010; 123: 2527 - 2532.