Immunosuppressants

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Immunosuppressants

An immunosuppressant is any endogenous or exogenous molecule that inhibits normal immune system response. They generally function by inhibiting production of white blood cells. Immunosuppressants can be useful in coercing the body to accept a transplanted organ.

FREE REVIEW ARTICLES

Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura, Donald M. Arnold, Ishac Nazi, et al. Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura. Blood, 2010; 115: 29 - 31.

The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors, Shawn G. Payne, Carole A. Oskeritzian, et al. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood, 2007; 109: 1077 - 1085.

The Immunosuppressant Cyclosporin A Antagonizes Human Formyl Peptide Receptor through Inhibition of Cognate Ligand Binding, Pangke Yan, Masakatsu Nanamori, et al. The Immunosuppressant Cyclosporin A Antagonizes Human Formyl Peptide Receptor through Inhibition of Cognate Ligand Binding. J. Immunol, 2006; 177: 7050 - 7058.

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Product Number	L-2170
CAS #	191732-72-6
Chemical Name	(R,S)-3-(4-amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
Chemical Formula	C₁₃H₁₃N₃O₃
Appearance	White to off-white solid
Molecular Weight	259.26
Purity	≥98% by HPLC
Solubility	DMSO (~100 mg/ml)
Storage Temp	-20°C

(R,S)-Lenalidomide Product Number: L-2170
Price	Price	Qty	Add to Cart
1x25 mg	$55.00
1x100 mg	$155.00

Product Number	A-2176
CAS #	108605-62-5
Chemical Name	N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Chemical Formula	C₁₂H₉F₃N₂O₂
Appearance	White solid
Molecular Weight	270.21
Purity	≥98% by HPLC
Solubility	DMSO
Storage Temp	-20°C

A77 1726 Product Number: A-2176
Price	Price	Qty	Add to Cart
1x5 mg	$75.00
1x25 mg	$285.00

Product Number	A-1258
CAS #	CAS [11011-38-4]
Chemical Formula	C₄₃H₆₉NO₁₂
Alternative Name	Immunomycin, FR-900520, FK520
Appearance	White Powder
Melting Point	MP: 162-164°C
Molecular Weight	M.W. 792.0
Preparation	Product is stable for 3 years as supplied. Ethanol Stock Solutions (1mg/ml) are stable for up to 3 days at -20°C.
Purity	Purity: >98%
Solubility	Solubility: Soluble in DMSO.
Storage Temp	-20°C

COA Documentation: A-1258, A8007B A-1258, A8103A, r02 Ascomycin, Streptomyces hygroscopicus var ascomyceticus Product Number: A-1258
Price	Price	Qty	Add to Cart
1x1 mg	$55.00
1x5 mg	$85.00
1x10 mg	$125.00

Product Number	C-2262
CAS #	34157-83-0
Chemical Name	(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Chemical Formula	C₂₉H₃₈O₄
Appearance	Red solid
Molecular Weight	450.61
Purity	≥98% by TLC
Solubility	DMSO (45 mg/ml) or Ethanol (30 mg/ml)
Storage Temp	-20°C

Celastrol Product Number: C-2262
Price	Price	Qty	Add to Cart
1x5 mg	$60.00
1x25 mg	$230.00

Product Number	C-1443
CAS #	CAS [1403-36-7]
Chemical Formula	C₃₁H₃₀N₆O₆S₄
Alternative Name	Chaetomin
Appearance	Off-white solid
Molecular Weight	M.W. 710.9
Purity	Purity: >98% by HPLC
Solubility	Soluble in DMSO, ethyl acetate or pyridin; moderately soluble in methanol, 100% ethanol; insoluble in water.
Storage Temp	+4°C

COA Documentation: C-1443, B1101 Chetomin Product Number: C-1443
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1x1 mg	$355.00

Product Number	C-1199
CAS #	CAS [59865-13-3]
Chemical Formula	C₆₂H₁₁₁N₁₁O₁₂
Alternative Name	Ciclosporin, Cyclosporin A, Ramihyphin A
Appearance	White powder
Merck Index	Merck Index: 13.2781.2001
Molecular Weight	M.W. 1202.6
Purity	Purity: ≥98%
Solubility	Soluble in DMSO (25mg/ml), methanol, 100% ethanol (25mg/ml), or acetone. Insoluble in water
Storage Temp	-20°C

COA Documentation: C-1199, A8587, r01 Cyclosporin A, Fusarium solani Product Number: C-1199
Price	Price	Qty	Add to Cart
1x100 mg	$55.00
1x500 mg	$215.00

Product Number	F-1030
CAS #	CAS [104987-11-3]
Chemical Formula	C₄₄H₆₉NO₁₂
Alternative Name	Tacrolimus, FR-900506, Prograf, Protopic
Appearance	Off-White Solid
Melting Point	MP: 119-121°C*
Merck Index	Merck Index: 13.9117.2001
Molecular Weight	M.W. 804.0
Preparation	Also reported to provide clear solution at >10mg/ml CH2CI2
Purity	Purity: ≥99%
Solubility	Soluble in DMSO, MeOH, also ETOAC.
Storage Temp	-20°C

MSDS Documentation: F-1030, FK-506, MSDS COA Documentation: F-1030, C1055 F-1030, B1310 FK-506, Tacrolimus Product Number: F-1030
Price	Price	Qty	Add to Cart
1x5 mg	$38.00
1x10mg	$60.00
1x25 mg	$138.00

Product Number	I-1306
CAS #	CAS [479-41-4]
Chemical Formula	C₁₆H₁₀N₂O₂
Appearance	Purple Powder
Molecular Weight	M.W. 262.3
Purity	Purity: ≥98% by HPLC
Solubility	Soluble in DMSO (10 mg/ml) or methanol (0.3 mg/ml). Sparingly soluble in aqueous buffers (12.5 μg/ml).
Storage Temp	+4°C

COA Documentation: I-1306, A10034 Indirubin, High Purity Research Grade Product Number: I-1306
Price	Price	Qty	Add to Cart
1x1 mg	$51.00
1x5 mg	$215.00

Product Number	L-2372
CAS #	75706-12-6
Chemical Name	5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide), N-(4-Trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide; HWA486,
Chemical Formula	C₁₂H₉F₃N₂O₂
Appearance	White to off-white solid
Molecular Weight	270.21
Purity	≥98% by HPLC
Solubility	DMSO (100 mM) or Ethanol (100 mM)
Storage Temp	-20°C

COA Documentation: L-2372, D1005 Leflunomide Product Number: L-2372
Price	Price	Qty	Add to Cart
1x10 mg	$55.00
1x50 mg	$145.00

Product Number	R-1018
CAS #	CAS [53123-88-9]
Chemical Name	Isolated from Streptomyces hygroscopicus
Chemical Formula	C₅₁H₇₉NO₁₃
Alternative Name	RAPA, Rapamune, Sirolimus, AY-22989, NSC-226080
Appearance	White to Off White Solid
Melting Point	MP: 183-185°C
Merck Index	Merck Index: 13.8202.2001
Molecular Weight	M.W. 914.2
Purity	Purity: >98%
Solubility	Soluble in DMSO and Methanol.
Storage Temp	-20°C

COA Documentation: R-1018, A9560A, r01 R-1018, C1065 R-1018, C1188 Rapamycin \| Immunosuppressive Antibiotic Product Number: R-1018
Price	Price	Qty	Add to Cart
1x1 mg	$22.00
1x5 mg	$62.00
1x25 mg	$202.00

Product Number	R-2420
CAS #	84573-16-0
Chemical Name	Rocaglamide A
Chemical Formula	C₂₉H₃₁NO₇
Appearance	White to off-white solid
Molecular Weight	505.56
Purity	≥98% by HPLC
Solubility	DMSO or EtOH
Storage Temp	-20°C

COA Documentation: R-2420, C1339 Rocaglamide Product Number: R-2420
Price	Price	Qty	Add to Cart
1x100 ug	$345.00

Product Number	W-1042
CAS #	CAS[5119-48-2]
Chemical Name	[5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide]
Chemical Formula	C₂₈H₃₈O₆
Alternative Name	Isolated from Whithania somnifera
Appearance	White to off-white solid.
Merck Index	Merck: 14:10048
Molecular Weight	M.W.470.6
Purity	Purity:≥98% (HPLC)
RTECS	KE7288500
Solubility	DMSO (20 mg/ml), methanol (10 mg/ml), 100% ethanol
Storage Temp	-20°C

COA Documentation: W-1042, B1989 Withaferin A \| CAS#5119-48-2 \| Angiogenesis Inhibitor, Immunosuppressant Product Number: W-1042
Price	Price	Qty	Add to Cart
1x10 mg	$540.00

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