You have no items in your shopping cart.

Subtotal: $0.00

Toll Free:(877) 452-9925

Blasticidin S HCl

More Views

Blasticidin S HCl

CAS: 3513-03-9 Formula: C17H26N8O5.HCl MW: 458.904 Appearance: White to off-white Powder Purity: 98%
Hazardous

4

0

0

0

PRODUCT # SIZE LIST PRICE QUANTITY BUY NOW BULK INQUIRIES
B-1247 25 mg
$108.83
Bulk Inquiry
100 mg
$191.00
Bulk Inquiry
1 g
$1,400.00
Bulk Inquiry

BULK INQUIRY FORM

* Required Fields

*
*
*
*
*
*Bulk OEM Multiple Catalog Custom Other
Prod# CAS# *PRODUCT NAME Grade *Size *Qty Time Frame

Custom magento captcha module from Outsource Online  

Blasticidin S is an aminoacylnucleoside antibiotic isolated from Streptomyces griseochromogenes. It shows high efficacy against both eukaryotic and prokaryotic cells. Aside from its antimicrobial properties, blasticidin has displayed antiviral, antitumor, and antifungal properties and has been used as a selection agent. It has been used to select for cells containing the blsbsr, or BSD resistance gene as well as HEK293-T cells and HEK-D5 cells. Additionally, blasticidin is effective in preventing cell culture contamination and studying protein synthesis.

Blasticidin S functions by inhibiting peptide bond formation at the ribosome. It blocks hydrolysis of peptidyl-tRNA due to the large ribosomal subunit's increased affinity for tRNA.

Blasticidin S, longstanding application as a gene selection antibiotic, has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system1,2. Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in Duchenne muscular dystrophy (DMD)3.

1.)   http://www.genetics.org/content/genetics/197/4/1069.full.pdf

2.)   http://www.g3journal.org/content/early/2016/04/11/g3.116.028241.full.pdf+html

3.)    http://nar.oxfordjournals.org/content/44/3/1449.full.pdf+html

Additional Information

Product # B-1247
CAS # 3513-03-9
Chemical Name (2S,3S,6R)-3-[[(3S)-3-AMINO-5-[CARBAMIMIDOYL(METHYL)AMINO]PENTANOYL]AMINO]-6-(4-AMINO-2-OXOPYRIMIDIN-1-YL)-3,6-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID HYDROCHLORIDE
Formula C17H26N8O5.HCl
MW 458.904
Appearance White to off-white Powder
Purity 98%
Solubility Soluble in water. Insoluble in organic solvents.
Melting Point 218.0-225.0 °C
Boiling Point 772.1 °C at 760 mmHg
Storage Temp +4°C
Use An antibiotic inhibiting protein synthesis

Additional Information

MDL Number MFCD02091640
ChemACX X1339381-2
InChI InChI=1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H
SMILES [H]/N=C(N)/N(C)CCC(CC(=O)NC1C=CC(OC1C(=O)O)n2ccc(nc2=O)N)N.Cl

Additional Information

GHS Pictograms
UN #'S UN 2811
PACKING GROUP II
Handling Warning.Toxic. Store in Tightly Sealed Vial Protect from moisture.

Additional Information

msds 1 B-1247, SDS.pdf
Certificate of Analysis 1 B-1247, G1327.pdf
Certificate of Analysis 2 B-1247, G1218B.pdf
Certificate of Analysis 3 B-1247, G1218A.pdf

Additional Information

Additional Information

Blasticidin S HCl

USD

$0.00

0