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Product Description
FITC labeled mammalian calmodulin. FITC labeled mammalian calmodulin. CaM functions as an intracellular calcium ion bridge to mediate cellular reactions and responds appropriately to calcium ion concentration. In Alzheimer's disease (AD), irregular calcium homeostasis seems to trigger CaM and its binding proteins, to enhance plaque formation and neurofibrillary degeneration, which results in cell death. In Parkinson's disease (PD), Calmodulin has been found to interact, in a calcium dependent manner, with Alpha-Synuclein, which is associated with the progression of PD. CaM was identified as one of the synuclein-interacting proteins that regulate synuclein conformation.
1) FM LaFerla. 2002, Nature Reviews Neurosci. 3: 862-872.
2) Martinez J., et al., 2003, J. of Biological Chemistry. 278:17379.
Additional Information
COA Documentation: |
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| Product Number | C-1435 |
| Appearance | Lyophilized from 5% sucrose, 10 mM sodium phosphate, pH 7.0 at a protein concentration of approximately 1 mg per ml in a dark plastic screw-cap 1.5 ml vial. |
| Purity | Physical Purity: > 98% by SDS-PAGE stained with Coomassie blue having a single band at approximately 17 kDa. Activity: Greater than 35,000 units per mg protein. One unit will stimulate 0.01 unit of 3′:5′-cyclic nucleotide phosphodiesterase in a 3 ml reaction volume at pH 7.5 and 30°C, to 50% of the maximum activity of the enzyme when saturated with CaM in the presence of 100 μM Ca2+. Fluorochrome/Protein Ratio: fluorescein /CaM = 0.5 to 1.0 as determined by absorbance. |
| Storage Temp | -20°C. |
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