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Protein A

Protein A is a 56 kDa MSCRAMM surface protein originally found in the cell wall of the bacterium Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has found use in biochemical research because of its ability to bind immunoglobulins. It is composed of five homologous Ig-binding domains that fold into a three-helix bundle. Each domain is able to bind proteins from many of mammalian species, most notably IgGs. It binds the heavy chain with the Fc region of most immunoglobulins and also within the Fab region in the case of the human VH3 family. Through these interactions in serum, where IgG molecules are bound in the wrong orientation (in relation to normal antibody function), the bacteria disrupts opsonization and phagocytosis. 

AG Scientific can ship FedEx directly to your lab, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

 

 

  1. Protein A, Recombinant (Liquid Form)

    Protein A, Recombinant (Liquid Form)

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2411 10 mg
    $98.23
    25 mg
    $211.97
    100 mg
    $672.10
    1 g
    $1,788.82
  2. Protein A, Recombinant (Lyophilized)

    Protein A, Recombinant (Lyophilized)

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2412 10 mg
    $98.23
    25 mg
    $211.97
    100 mg
    $672.10
    1 g
    $1,788.82
  3. Protein A/G/L, Recombinant

    Protein A/G/L, Recombinant

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2416 1 mg
    $108.57
    5 mg
    $310.20
    25 mg
    $1,085.70
    100 mg
    $3,308.80
    1 g
    $16,285.50