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Product Description
Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.
Wang, H. and Yan, C. (2011). Neoplasia.
Berkson, R.G., et al. (2005). Int. J. Cancer.
Dolma, S., et al. (2003). Cancer Cell 3.
Additional Information
| Product Number | N-1215 |
| CAS # | [59474-01-0] |
| Chemical Formula | C17H16N2S.HCl |
| Appearance | Yellow Solid |
| Molecular Weight | 316.85 |
| Purity | ≥ 98% |
| Solubility | Soluble in DMSO & Ethanol. |
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All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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