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Cell Cycle

The cell cycle is the replication process for a cell. A eukaryotic cell starts as a 2N (diploid) cell, replicates its DNA to become a 4N cell, then divides to become two diploid cells. Most of the time is spent in preparation phases, or gap (G1 and G2) phases, preparing for DNA replication and cell division, respectively. Mitosis, cell division, is the shortest phase in the cell cycle. A.G. Scientific has over 200 molecules and reagents to aid your research, our most popular cell cycle inhibitors are:

PD 98059 is a cell-permeable, potent and specific inhibitor of MAP Kinase (MEK or MAPK/ERK). By selectively blocking the activity of MEK, it also inhibits the phosphorylation and activation of MAP kinase.

Radicicol is an antifungal antibiotic which acts as a Hsp90-specific inhibitor.

Trichostatin A is an antifungal antibiotic that is a potent and specific inhibitor of mammalian histone deacetylase (HDAC) both in vivo and in vitro. TSA inhibits the eukaryotic cell cycle and induces morphological reversion of transformed cells. Blocks cell cycle progression at G1 phase in Hela Cell.

A.G. Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

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(+)-Aphidicolin, Nigrospora oryzae
Product Number: A-1026

Product Name Price Qty
(+)-Aphidicolin, Nigrospora oryzae - 1x1 mg
$55.00
(+)-Aphidicolin, Nigrospora oryzae - 1x5 mg
$185.00
(+)-Aphidicolin, Nigrospora oryzae - 1x25 mg
$670.00
Reversible Inhibitor of eukaryotic nuclear DNA replication. Learn More

(+)-cis,trans-Abscisic Acid
Product Number: A-1103

Product Name Price Qty
(+)-cis,trans-Abscisic Acid - 1x1 g
$175.00
(+)-cis,trans-Abscisic Acid - 1x5 g
$710.00
(+)-cis,trans-Abscisic Acid - 1x10 g
$1,150.00
Natural isomer of the abscission accelerating plant hormone. Learn More

(S)-Roscovitine
Product Number: R-2022

Product Name Price Qty
(S)-Roscovitine - 1x1 mg
$40.00
the (S)-enantiomer of the potent cyclin-dependent kinase (cdk) inhibitor Roscovitine (#R1016). Potently inhibits p34cdc2/cyclin B kinase (IC Learn More

(trans, trans)-Abscisic Acid
Product Number: A-1124

Product Name Price Qty
(trans, trans)-Abscisic Acid - 1x50 mg
$400.00

(±)-cis,trans-Abscisic Acid
Product Number: A-1094

Product Name Price Qty
(±)-cis,trans-Abscisic Acid - 1x1 g
$175.00
(±)-cis,trans-Abscisic Acid - 1x5 g
$710.00
A plant hormone involved in plant growth and stress response. Learn More

10z-Hymenialdisine
Product Number: H-1150

Product Name Price Qty
10z-Hymenialdisine - 1x500 μg
$185.00
Potent inhibitor of mitogen-activated protein kinase kinase-1, Inhibitor of G2 DNA damage checkpoint and cyclin-dependent kinases CDK1/cycli Learn More

17-AAG
Product Number: A-1256

Product Name Price Qty
17-AAG - 1x500 μg
$50.00
17-AAG - 1x1 mg
$70.00
17-AAG - 1x5mg
$185.00
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Learn More

17DMAG
Product Number: A-1298

Product Name Price Qty
17DMAG - 1x1mg
$70.00
17DMAG - 1x5 mg
$185.00
A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Gelda Learn More

20-Hydroxyecdysone
Product Number: H-1094

Product Name Price Qty
20-Hydroxyecdysone - 1x10 mg
$90.00
20-Hydroxyecdysone - 1x50 mg
$345.00
Most widely occurring ecdysteroid in both plant and animal species. Learn More

5-Iodo-indirubin-3'-monoxime
Product Number: I-1308

Product Name Price Qty
5-Iodo-indirubin-3'-monoxime - 1x1 mg
$90.00
Potent inhibitor of GSK-3Beta (IC50=9nM). Also inhibits CDK1/cyclin B (IC50=25nM) and CDK5/p25 (IC50=20nM) by binding to the ATP-binding poc Learn More

ACRP30, Soluble (Mouse) (Recombinant)
Product Number: A-1274

Product Name Price Qty
ACRP30, Soluble (Mouse) (Recombinant) - 1x50 μg
$330.00
Source: Produced in HEK 293. Mouse ACRP30 (aa 18-247) fused at the N-terminus to a linker peptide (8 aa) and a FLAG tag. Reconstitution: Rec Learn More

ACRP30headless (Human)
Product Number: A-1272

Product Name Price Qty
ACRP30headless (Human) - 1x10 μg
$265.00
Source: Produced in HEK 293 cells. The non-homologous (aa16-45) and collagen domain of human ACRP30 (aa 45-108) are fused at the N-terminus Learn More

Actinomycin D, Streptomyces sp.
Product Number: A-1022

Product Name Price Qty
Actinomycin D, Streptomyces sp. - 1x5 mg
$45.00
Actinomycin D, Streptomyces sp. - 1x10 mg
$70.00
Actinomycin D, Streptomyces sp. - 1x25 mg
$155.00
Actinomycin D, Streptomyces sp. - 1x100 mg
$455.00
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymera Learn More

AG 1007
Product Number: A-1180

Product Name Price Qty
AG 1007 - 1x1 mg
$50.00
AG 1007 - 1x5 mg
$148.00

AG 1024
Product Number: A-1178

Product Name Price Qty
AG 1024 - 1x1 mg
$65.00
AG 1024 - 1x5 mg
$248.00
An inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Learn More

AG 1517, PD 153035
Product Number: P-1237

Product Name Price Qty
AG 1517, PD 153035 - 1x5 mg
$84.00
AG 1517, PD 153035 - 1x25 mg
$328.00
A tyrosine kinase inhibitor. Also inhibits Epidermal Growth Factor. Learn More

AG 370
Product Number: A-1186

Product Name Price Qty
AG 370 - 1x2 mg
$90.00
AG 370 - 1x10 mg
$365.00
Inhibitor of platelet derived growth factor (PDGF) autophosphorylation and PDGF-induced mitogenesis. Learn More

AG 808
Product Number: A-1184

Product Name Price Qty
AG 808 - 1x5 mg
$45.00
AG 808 - 1x25 mg
$128.00

AG 825
Product Number: A-1182

Product Name Price Qty
AG 825 - 1x2 mg
$70.00
AG 825 - 1x10 mg
$280.00
Selective inhibitor of HER2 compared to HER1 (IC50=0.35uM vs. 19uM for EGFR and 40uM for PDGFR). Learn More

Aminogenistein
Product Number: A-1106

Product Name Price Qty
Aminogenistein - 1x1 mg
$218.00
Inhibits the Protein-Tyrosine Kinase Activity of p56lck. Learn More

Aminopurvalanol A
Product Number: A-1310

Product Name Price Qty
Aminopurvalanol A - 1x1 mg
$45.00
Aminopurvalanol A - 1x5 mg
$135.00
Cell permeable, reversible and competitive inhibitor of CDK1/cyclin B (IC50=33nM), CDK2/cyclin A (IC50=33nM), CDK2/cyclin E (IC50=28nM) and Learn More

Ampullosporin A
Product Number: A-1266

Product Name Price Qty
Ampullosporin A - 1x1 mg
$48.00
Ampullosporin A - 1x5 mg
$195.00
Induces pigment formation by the fungus Phoma destructiva, causes hypothermia in mice, displays neuroleptic activity in rats and forms insta Learn More

Antimycin A
Product Number: A-1268

Product Name Price Qty
Antimycin A - 1x10 mg
$33.00
Induces apoptosis, which is not prevented by the presence of bcl-2. Inhibits mitochondrial electron transport specifically between cytochrom Learn More

Apicidin
Product Number: A-1264

Product Name Price Qty
Apicidin - 1x1 mg
$45.00
Apicidin - 1x5 mg
$190.00
Potent inhibitor of histone deacetylase (HDAC) (IC50=700pM). Learn More

Apigenin
Product Number: A-1108

Product Name Price Qty
Apigenin - 1x20 mg
$69.00
Apigenin - 1x100 mg
$278.00
A MAP Kinase inhibitor; and a selective inhibitor of CK2.    Chemopreventive and anti-tumor properties - inhibits proliferation of maligna Learn More

ARL-67156
Product Number: A-1067

Product Name Price Qty
ARL-67156 - 1x10 mg
$235.00
An ecto-ATPase inhibitor. Learn More

Aurantimycin A
Product Number: A-1270

Product Name Price Qty
Aurantimycin A - 1x1 mg
$25.00
Aurantimycin A - 1x5 mg
$98.00
Strong antibiotic activity against gm-positive bacteria and cytotoxicity. Shows inhibitory effects on cellular adhesion and anaphylatoxin re Learn More

Bafilomycin A1 from Streptomyces griseus
Product Number: B-1183

Product Name Price Qty
Bafilomycin A1 from Streptomyces griseus - 1x1 mg
$165.00
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Useful in distinguishing among different types of ATPas Learn More

Bafilomycin B1 from Streptomyces griseus
Product Number: B-1185

Product Name Price Qty
Bafilomycin B1 from Streptomyces griseus - 1x1 mg
$70.00
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Learn More

Bafilomycin B2
Product Number: B-1245

Product Name Price Qty
Bafilomycin B2 - 1x50 mg
$0.00
from Streptomyces griseus. Inquire for availability. Learn More

Blasticidin S . HCl
Product Number: B-1247

Product Name Price Qty
Blasticidin S . HCl - 1x100 mg
$165.00
Blasticidin S . HCl - 5x 2 ml
$180.00
Inhibitor of DNA and protein synthesis. Blasticidin S is a peptidyl nuncleoside antibiotic isolated from the culture broth of Stretomyces gi Learn More

Bohemine
Product Number: B-1283

Product Name Price Qty
Bohemine - 1x1 mg
$39.00
Bohemine - 1x5 mg
$118.00
Cell permeable inhibitor of CDK1 (IC ₅₀=1.1 µM) and CD2 (IC₅₀=600 nM). Arrests cell cycle in the G₁/S boundary and activates matu Learn More

Bongkrekic Acid.3NH3
Product Number: B-1053

Product Name Price Qty
Bongkrekic Acid.3NH3 - 1x100 μg
$115.00
An inhibitor of the mitochondrial permeability transition. It acts as an inhibitory ligand of the mitochondrial adenine nucleotide transloca Learn More

Borrelidin, Streptomyces sp.
Product Number: B-1260

Product Name Price Qty
Borrelidin, Streptomyces sp. - 1x1mg
$237.00
Borrelidin, an 18-membered macrolide-polyketide, is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic propertie Learn More

Brefeldin A, Eupenicillium brefeldianum
Product Number: B-1009

Product Name Price Qty
Brefeldin A, Eupenicillium brefeldianum - 1x10 mg
$120.00
Brefeldin A, Eupenicillium brefeldianum - 1x25 mg
$260.00
Brefeldin A, Eupenicillium brefeldianum - 1x100 mg
$735.00
Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus. Learn More

Calcitriol
Product Number: C-1026

Product Name Price Qty
Calcitriol - 1x100 ug
$150.00
Biologically active form of Vitamin D3 in intestinal calcium transport and bone calcium reabsorption. Stimulates Osteoprotegerin. Learn More

Camptothecin
Product Number: C-1261

Product Name Price Qty
Camptothecin - 1x250 mg
$147.00
Camptothecin - 1x1 g
$294.00
Inhibitor of nuclear topoisomerase I by binding to and trapping the topoisomerase-DNA covalent complex. Learn More

CDK1/2 Inhibitor III
Product Number: C-1447

Product Name Price Qty
CDK1/2 Inhibitor III - 1x1 mg
$175.00
Cell permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50=20nM, 35nM and 92nM Learn More

Chartreusin
Product Number: C-1371

Product Name Price Qty
Chartreusin - 1x5 mg
$50.00
Chartreusin - 1x25 mg
$195.00
Antitumor antibiotic which inhibits topoisomerase II. Induces single-strand scission in DNA in the presence of reducing agents. Learn More

Chetomin, Chaetomium species
Product Number: C-1443

Product Name Price Qty
Chetomin, Chaetomium species - 1x1 mg
$185.00
Chetomin, Chaetomium species - 1x5 mg
$495.00
Dithiodiketopiperazine inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF(Hypoxia-inducible Factor)-1alpha and HIF-2 Learn More

Chromomycin A3 Streptomyces Griseus
Product Number: C-1023

Product Name Price Qty
Chromomycin A3 Streptomyces Griseus - 1x5 mg
$105.00
Chromomycin A3 Streptomyces Griseus - 1x10 mg
$185.00
Antibiotic produced by Streptomyces grieus that inhibits RNA synthesis. Also used as a fluorescent dye to determine DNA concentrations. Othe Learn More

clasto-Lactacystin β-lactone, Synthetic
Product Number: L-1055

Product Name Price Qty
clasto-Lactacystin β-lactone, Synthetic - 1x100 μg
$189.00
Synthetic. Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. It is believed lactacystin acts as a precursor for cl Learn More

COMP, Rat: Angiopoietin-1, Soluble, Human, Recombinant
Product Number: A-1304

Product Name Price Qty
COMP, Rat: Angiopoietin-1, Soluble, Human, Recombinant - 1x10 ug
$368.00
COMP, Rat: Angiopoietin-1, Soluble, Human, Recombinant - 1x50 ug
$990.00
Induces phosphorylation of Tie-2 in primary cultured human and mouse vascular endothelial cells. More potent than native Ang-1. The fibrinog Learn More

Compound 52
Product Number: C-1553

Product Name Price Qty
Compound 52 - 1x1 mg
$55.00
Potent, cell permeable and selective inhibitor of CDK1 (IC₅₀=340nM) the cell cycle -regulating kinase Cdc28p (IC₅₀=7µM) and the rel Learn More

Cytochalasin A
Product Number: C-1111

Product Name Price Qty
Cytochalasin A - 1x5 mg
$165.00
Cytochalasin A - 1x10 mg
$285.00
A fungal metabolite that acts as an inhibitor of glucose transport and actin polymerization. Learn More

Cytochalasin B, Helminthosporium dematioideum
Product Number: C-1027

Product Name Price Qty
Cytochalasin B, Helminthosporium dematioideum - 1x5 mg
$87.00
Cytochalasin B, Helminthosporium dematioideum - 1x25 mg
$370.00
A fungal metabolite that acts as a microtubule inhibitor. Also induces cellular DNA Fragmentation. Learn More

Cytochalasin C
Product Number: C-1200

Product Name Price Qty
Cytochalasin C - 1x1 mg
$70.00
Cytochalasin C - 1x5 mg
$280.00
A fungal metabolite that acts as a potent inhibitor of actin filament and contractile microfilaments. Learn More

Cytochalasin D, Zygusporium mansonii
Product Number: C-1070

Product Name Price Qty
Cytochalasin D, Zygusporium mansonii - 1x1 mg
$65.00
Cytochalasin D, Zygusporium mansonii - 1x5 mg
$258.00
A fungal metabolite that acts as a potent inhibitor of actin filament and contractile microfilaments. Also shown to protect Hippocampal neur Learn More

Cytochalasin E, Aspergillus clavatus
Product Number: C-1197

Product Name Price Qty
Cytochalasin E, Aspergillus clavatus - 1x1 mg
$38.00
Cytochalasin E, Aspergillus clavatus - 1x5 mg
$150.00
Cytochalasin E, Aspergillus clavatus - 1x10 mg
$275.00
A fungal metabolite that inhibits angiogenesis & tumor growth. Enhances PKC-dependent process of secretion. Does not inhibit glucose transpo Learn More

Daidzein
Product Number: D-1019

Product Name Price Qty
Daidzein - 1x25 mg
$40.00
Daidzein - 1x50 mg
$60.00
Inactive analog of the tyrosine kinase inhibitor genistein. Learn More

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